Tisotumab Vedotin in Cervical Cancer: Current Status and Future Perspectives

Despite the introduction of screening programmes and vaccination campaigns, cervical cancer (CC) still represents one of the leading causes of cancer-related mortality in women worldwide and the fourth most common female malignancy. The prognosis of CC remains poor, especially for late-stage and relapsed disease. While platinum-based chemotherapy with or without bevacizumab has been the established standard of care in the first-line setting, no standard second-line treatments have been identified, and new active agents are needed. Antibody–drug conjugates (ADCs) represent a novel class of agents approved by the US Food and Drug Administration to treat haematological malignancies and metastatic breast cancer. According to available data, ADCs could also represent a valid option for metastatic and recurrent CC. This review describes the role of tisotumab vedotin, an ADC targeting tissue factor, in the metastatic and recurrent CC setting. An overview of published data and ongoing clinical trials is also provided.