In the natural history of pressure overload, the hypertrophy response of the left ventricle initially normalizes wall stress and allows preservation of a normal ejection fraction. Nevertheless, patients progress gradually or suddenly from compensated hypertrophy to ventricular dilation with heart failure. Long-standing hypertrophy entails a maladaptive response, which is due to derangements inherent in the myocardium rather than to a progressive increase in the cause of pressure overload. Despite this condition being linked to major clinical consequences and an unfavourable prognosis, the cellular and molecular mechanisms in pressure-overload cardiomyopathy have not yet been established. This review discusses the available experimental and clinical evidence with respect to the role played by myocardial apoptosis in pressure-overload cardiomyopathy.

Anselmi, A., Gaudino, M. F. L., Baldi, A., Vetrovec, G., Bussani, R., Possati, G. F., Abbate, A., Role of apoptosis in pressure-overload cardiomyopathy, <<JOURNAL OF CARDIOVASCULAR MEDICINE>>, 2008; 9 (3): 227-232. [doi:10.2459/JCM.0b013e328277f1d7] [http://hdl.handle.net/10807/33329]

Role of apoptosis in pressure-overload cardiomyopathy

Gaudino, Mario Fulvio Luigi;Abbate, Antonio
2008

Abstract

In the natural history of pressure overload, the hypertrophy response of the left ventricle initially normalizes wall stress and allows preservation of a normal ejection fraction. Nevertheless, patients progress gradually or suddenly from compensated hypertrophy to ventricular dilation with heart failure. Long-standing hypertrophy entails a maladaptive response, which is due to derangements inherent in the myocardium rather than to a progressive increase in the cause of pressure overload. Despite this condition being linked to major clinical consequences and an unfavourable prognosis, the cellular and molecular mechanisms in pressure-overload cardiomyopathy have not yet been established. This review discusses the available experimental and clinical evidence with respect to the role played by myocardial apoptosis in pressure-overload cardiomyopathy.
Inglese
Anselmi, A., Gaudino, M. F. L., Baldi, A., Vetrovec, G., Bussani, R., Possati, G. F., Abbate, A., Role of apoptosis in pressure-overload cardiomyopathy, <<JOURNAL OF CARDIOVASCULAR MEDICINE>>, 2008; 9 (3): 227-232. [doi:10.2459/JCM.0b013e328277f1d7] [http://hdl.handle.net/10807/33329]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/33329
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