Background and aims Primary Progressive Aphasia (PPA) is a rare condition linked to various neurodegenerative disorders gradually impairing language functions, for which no specific pharmacological treatments are available. The efficacy of language training interventions in mitigating communication difficulties and of non-invasive stimulation technique, improving cortical plasticity and cognitive performance, have been previously proved in PPA. The aim of this study was to evaluate the neural correlates associated with cognitive improvements following rehabilitation. Methods Twelve people with PPA (pwPPA, 72.7 ± 8.4 age, 9F) underwent an MRI scanning session (3 T scanner) comprising functional sequences acquired in resting conditions before and after a language training with neuro-modulation. After standard preprocessing resting state networks (RSN) were derived from functional data. Through dual regression analysis the individual RSN were derived for each individual and compared between healthy control (HC) and patients. Significant differences retrieved from this comparison were used to drive further comparison to capture possible changes following rehabilitation in pwPPA. Results Significant higher activation in terms of amplitude and extension were highlighted for HC with respect to pwPPA within the auditory RSN. Furthermore, following rehabilitation higher activation was captured within left inferior frontal cortex (pars orbitalis), paracingulate cortex, and middle frontal cortex in pwPPA. Conclusions The changes observed in pwPPA following rehabilitation were located in language relevant brain areas and were interpreted as a restoration of neural activity considering the relevance of these areas in articulatory-phonological processes. Acknowledgment: MAINSTREAMA Multimodal Approach for Clinical Diagnosis and Treatment of Primary Progressive Aphasia. Bando Unmet Medical Needs H43C22001230002 - 3,430,931.
Pirastru, A., Blasi, V., Rossetto, F., Pagliari, C., Serenelli, C., Cotelli, M., Manenti, R., Baglio, F., Neural correlates of language rehabilitation in Primary ProgressiveAphasia: Insights from resting state FMRI, <<JOURNAL OF THE NEUROLOGICAL SCIENCES>>, 2025; (480): 40-40 [https://hdl.handle.net/10807/330277]
Neural correlates of language rehabilitation in Primary Progressive Aphasia: Insights from resting state FMRI
Blasi, Valeria;Rossetto, Federica;Pagliari, Chiara;Cotelli, Maria;Manenti, Rosa;Baglio, Francesca
2025
Abstract
Background and aims Primary Progressive Aphasia (PPA) is a rare condition linked to various neurodegenerative disorders gradually impairing language functions, for which no specific pharmacological treatments are available. The efficacy of language training interventions in mitigating communication difficulties and of non-invasive stimulation technique, improving cortical plasticity and cognitive performance, have been previously proved in PPA. The aim of this study was to evaluate the neural correlates associated with cognitive improvements following rehabilitation. Methods Twelve people with PPA (pwPPA, 72.7 ± 8.4 age, 9F) underwent an MRI scanning session (3 T scanner) comprising functional sequences acquired in resting conditions before and after a language training with neuro-modulation. After standard preprocessing resting state networks (RSN) were derived from functional data. Through dual regression analysis the individual RSN were derived for each individual and compared between healthy control (HC) and patients. Significant differences retrieved from this comparison were used to drive further comparison to capture possible changes following rehabilitation in pwPPA. Results Significant higher activation in terms of amplitude and extension were highlighted for HC with respect to pwPPA within the auditory RSN. Furthermore, following rehabilitation higher activation was captured within left inferior frontal cortex (pars orbitalis), paracingulate cortex, and middle frontal cortex in pwPPA. Conclusions The changes observed in pwPPA following rehabilitation were located in language relevant brain areas and were interpreted as a restoration of neural activity considering the relevance of these areas in articulatory-phonological processes. Acknowledgment: MAINSTREAMA Multimodal Approach for Clinical Diagnosis and Treatment of Primary Progressive Aphasia. Bando Unmet Medical Needs H43C22001230002 - 3,430,931.
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