Purpose: There may be sex-based disparities in intensive care unit (ICU) management and outcomes. We compared baseline variables, interventions, and outcomes of immunocompromised critically ill men and women. Methods: We performed a post hoc analysis of the Efraim study, a prospective multinational cohort study of immunocompromised adults with acute hypoxemic respiratory failure admitted to one of 68 ICU in 16 countries between November 2015 and July 2016. We compared in unadjusted and adjusted analyses baseline variables, ICU interventions, and outcomes between men and women. Results: We included 1536 immunocompromised adults (922 men, 614 women) in this study. Women and men had similar age, BMI, and diagnoses leading to immunosuppression; hematopoietic cell transplant was more common in men. On the first ICU day, SOFA score was higher in men vs. women (7 [IQR 4–10] vs 6 [4–10]), p = 0.0005). The use of ICU supportive interventions, including mechanical ventilation, vasopressors, renal replacement, bronchoalveolar lavage, and ARDS adjuncts, were similar between men and women; as were mortality in ICU, in hospital, and at 90 days. After adjustment, female sex (sub-hazard ratio 1.19, 95 % CI 1.05–1.36, p = 0.007), SOFA score on ICU day 1 (sHR 1.16, 95 % CI 1.12–1.19, p < 0.001) and chronic kidney disease (sHR 0.74, 95 % CI 0.59–0.93, p = 0.009) were associated with mechanical ventilation. Age, performance status and SOFA score on ICU day 1 were associated with hospital mortality. Conclusions: In this post hoc analysis of immunocompromised adult ICU patients with hypoxemic respiratory failure, women and men received similar ICU interventions, and had similar outcomes.
Mehta, S., Azoulay, E., Munshi, L., Demoule, A., Perner, A., Meyhoff, T. S., Bauer, P. R., Metaxa, V., Pène, F., Girault, C., Soares, M., Taccone, F. S., Antonelli, M., Barbier, F., Barratt-Due, A., Bruneel, F., Bukan, R. B., Burghi, G., Chevret, S., Gaborit, B., Hemelaar, P., Kouatchet, A., Landburg, P. P., Lemiale, V., Martin-Loeches, I., Mokart, D., Moreau, A., Montini, L., Nielsen, L. B., Pickkers, P., Rello, J., Rusinova, K., Salluh, J., Schellongowski, P., Souppart, V., Terzi, N., Valkonen, M., Van De Louw, A., Darmon, M., Sex-based differences in ICU management and outcomes of immunocompromised patients: A post hoc analysis of the prospective multicenter multinational Efraim cohort, <<JOURNAL OF CRITICAL CARE>>, 2025; 89 (N/A): 1-7. [doi:10.1016/j.jcrc.2025.155149] [https://hdl.handle.net/10807/325398]
Sex-based differences in ICU management and outcomes of immunocompromised patients: A post hoc analysis of the prospective multicenter multinational Efraim cohort
Antonelli, Massimo;Montini, Luca;
2025
Abstract
Purpose: There may be sex-based disparities in intensive care unit (ICU) management and outcomes. We compared baseline variables, interventions, and outcomes of immunocompromised critically ill men and women. Methods: We performed a post hoc analysis of the Efraim study, a prospective multinational cohort study of immunocompromised adults with acute hypoxemic respiratory failure admitted to one of 68 ICU in 16 countries between November 2015 and July 2016. We compared in unadjusted and adjusted analyses baseline variables, ICU interventions, and outcomes between men and women. Results: We included 1536 immunocompromised adults (922 men, 614 women) in this study. Women and men had similar age, BMI, and diagnoses leading to immunosuppression; hematopoietic cell transplant was more common in men. On the first ICU day, SOFA score was higher in men vs. women (7 [IQR 4–10] vs 6 [4–10]), p = 0.0005). The use of ICU supportive interventions, including mechanical ventilation, vasopressors, renal replacement, bronchoalveolar lavage, and ARDS adjuncts, were similar between men and women; as were mortality in ICU, in hospital, and at 90 days. After adjustment, female sex (sub-hazard ratio 1.19, 95 % CI 1.05–1.36, p = 0.007), SOFA score on ICU day 1 (sHR 1.16, 95 % CI 1.12–1.19, p < 0.001) and chronic kidney disease (sHR 0.74, 95 % CI 0.59–0.93, p = 0.009) were associated with mechanical ventilation. Age, performance status and SOFA score on ICU day 1 were associated with hospital mortality. Conclusions: In this post hoc analysis of immunocompromised adult ICU patients with hypoxemic respiratory failure, women and men received similar ICU interventions, and had similar outcomes.
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