Mutations of the nucleophosmin (NPM1) gene represent the most common genetic lesion in adult acute myeloid leukemia (AML), occurring in about one-third of cases and 60% of AML with normal cytogenetics.1 Due to its unique molecular, pathological and clinical features,2, 3 NPM1-mutated AML is now recognized as a distinct entity in the 2022 International Consensus4 and World Health Organization (WHO) 5th edition5 classifications of myeloid neoplasms.
Sica, S., Starry sky pattern predicts RAS pathway activation in NPM1-mutated acute myeloid leukemia, <<AMERICAN JOURNAL OF HEMATOLOGY>>, 2024; (1): 139-143 [https://hdl.handle.net/10807/312558]
Starry sky pattern predicts RAS pathway activation in NPM1-mutated acute myeloid leukemia
Sica, Simona
Penultimo
Membro del Collaboration Group
2024
Abstract
Mutations of the nucleophosmin (NPM1) gene represent the most common genetic lesion in adult acute myeloid leukemia (AML), occurring in about one-third of cases and 60% of AML with normal cytogenetics.1 Due to its unique molecular, pathological and clinical features,2, 3 NPM1-mutated AML is now recognized as a distinct entity in the 2022 International Consensus4 and World Health Organization (WHO) 5th edition5 classifications of myeloid neoplasms.
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