The S100B protein is abundant in the nervous system, mainly in astrocytes, and is also present in other districts. Among these, the adipose tissue is a site of concentration for the protein. In the light of consistent research showing some associations between S100B and adipose tissue in the context of obesity, metabolic disorders, and diabetes, this review tunes the possible role of S100B in the pathogenic processes of these disorders, which are known to involve the adipose tissue. The reported data suggest a role for adipose S100B in obesity/diabetes processes, thus putatively re-proposing the role played by astrocytic S100B in neuroinflammatory/neurodegenerative processes.

Michetti, F., Di Sante, G., Clementi, M. E., Valeriani, F., Mandarano, M., Ria, F., Di Liddo, R., Rende, M., Romano Spica, V., The Multifaceted S100B Protein: A Role in Obesity and Diabetes?, <<INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES>>, 2024; 25 (2): N/A-N/A. [doi:10.3390/ijms25020776] [https://hdl.handle.net/10807/302184]

The Multifaceted S100B Protein: A Role in Obesity and Diabetes?

Michetti, Fabrizio;Clementi, Maria Elisabetta;Ria, Francesco;
2024

Abstract

The S100B protein is abundant in the nervous system, mainly in astrocytes, and is also present in other districts. Among these, the adipose tissue is a site of concentration for the protein. In the light of consistent research showing some associations between S100B and adipose tissue in the context of obesity, metabolic disorders, and diabetes, this review tunes the possible role of S100B in the pathogenic processes of these disorders, which are known to involve the adipose tissue. The reported data suggest a role for adipose S100B in obesity/diabetes processes, thus putatively re-proposing the role played by astrocytic S100B in neuroinflammatory/neurodegenerative processes.
2024
Inglese
Michetti, F., Di Sante, G., Clementi, M. E., Valeriani, F., Mandarano, M., Ria, F., Di Liddo, R., Rende, M., Romano Spica, V., The Multifaceted S100B Protein: A Role in Obesity and Diabetes?, <<INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES>>, 2024; 25 (2): N/A-N/A. [doi:10.3390/ijms25020776] [https://hdl.handle.net/10807/302184]
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