A 70-year-old female patient with no known medical history presented in our ER with irradiating lumbar pain. CBC revealed moderate leukocytosis (WBC 25,000/mm3), severe thrombocytopenia (16,000/mm3), and moderate anemia (9.5 g/dL). Bone marrow (BM) aspirate (Fig. 1) revealed an infiltrate of blasts negative for myeloperoxidase (MPO) representing 65% of BM cellularity and trilineage dysplasia, compatible with a morphologic diagnosis of acute erythroid leukemia (AEL). Urgent molecular assays were positive for BCR/ABL1. The patient’s clinical conditions rapidly deteriorated, and despite maximal broad-spectrum antibiotics and vasopressors, the patient later succumbed to urosepsis in the ICU.
Marra, J. D., Frioni, F., Minnella, G., Rossi, M., Malara, T., Bellesi, S., Maiolo, E., Orteschi, D., Galli, E., Bacigalupo, A., Pagano, L., Sica, S., Zini Tanzi, G., Chiusolo, P., Acute erythroid leukemia with TP53 mutation and BCR/ABL1: challenges in classification and management, <<ANNALS OF HEMATOLOGY>>, 2024; 103 (3): N/A-N/A. [doi:10.1007/s00277-023-05561-3] [https://hdl.handle.net/10807/296757]
Acute erythroid leukemia with TP53 mutation and BCR/ABL1: challenges in classification and management
Marra, John Donald;Frioni, Filippo;Minnella, Gessica;Rossi, Monica;Malara, Tanja;Bellesi, Silvia;Maiolo, Elena;Galli, Eugenio;Bacigalupo, Andrea;Pagano, Livio;Sica, Simona;Zini Tanzi, Gina;Chiusolo, Patrizia
2024
Abstract
A 70-year-old female patient with no known medical history presented in our ER with irradiating lumbar pain. CBC revealed moderate leukocytosis (WBC 25,000/mm3), severe thrombocytopenia (16,000/mm3), and moderate anemia (9.5 g/dL). Bone marrow (BM) aspirate (Fig. 1) revealed an infiltrate of blasts negative for myeloperoxidase (MPO) representing 65% of BM cellularity and trilineage dysplasia, compatible with a morphologic diagnosis of acute erythroid leukemia (AEL). Urgent molecular assays were positive for BCR/ABL1. The patient’s clinical conditions rapidly deteriorated, and despite maximal broad-spectrum antibiotics and vasopressors, the patient later succumbed to urosepsis in the ICU.
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