There is no agreement on which channel is involved in oxaliplatin neurotoxicity, most investigators favouring voltage-gated sodium channels. However, the small conductance Ca(++) activated K(+) channels, encoded by the SK1-3 genes, are also involved in membrane excitability, playing a role in after-hyperpolarization at the motor nerve terminal. As the SK3 gene is characterized in Caucasians by a highly polymorphic CAG motif within the exon 1, we hypothesize that SK3 gene polymorphism may influence the development of acute nerve hyperexcitability in oxaliplatin-treated patients.
Basso, M., Modoni, A., Spada, D., Cassano, A., Schinzari, G., Lo Monaco, M., Quaranta, D., Tonali, P., Barone, C. A., Polymorphism of CAG motif of SK3 gene is associated with acute oxaliplatin neurotoxicity, <<CANCER CHEMOTHERAPY AND PHARMACOLOGY>>, 2011; 67 (5): 1179-1187. [doi:10.1007/s00280-010-1466-y] [http://hdl.handle.net/10807/29530]
Polymorphism of CAG motif of SK3 gene is associated with acute oxaliplatin neurotoxicity
Basso, Michele;Modoni, Anna;Spada, Danilo;Cassano, Alessandra;Schinzari, Giovanni;Lo Monaco, Mauro;Quaranta, Davide;Barone, Carlo Antonio
2011
Abstract
There is no agreement on which channel is involved in oxaliplatin neurotoxicity, most investigators favouring voltage-gated sodium channels. However, the small conductance Ca(++) activated K(+) channels, encoded by the SK1-3 genes, are also involved in membrane excitability, playing a role in after-hyperpolarization at the motor nerve terminal. As the SK3 gene is characterized in Caucasians by a highly polymorphic CAG motif within the exon 1, we hypothesize that SK3 gene polymorphism may influence the development of acute nerve hyperexcitability in oxaliplatin-treated patients.
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