Chronic inflammation and subsequent tissutal alterations may play a key role in prostate carcinogenesis. In this way, molecular alterations of the suppressor of cytokine signaling 3 (SOCS3), one of the most important inhibitory molecule of inflammatory signal transduction circuitries, could contribute to explain the pleiotropic role of interleukin-6 (IL-6) in this type of cancer.
Pierconti, F., Martini, M., Pinto, F., Cenci, T., Capodimonti, S., Calarco, A., Bassi, P., Larocca, L. M., Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior, <<THE PROSTATE>>, 2011; 71 (3): 318-325. [doi:10.1002/pros.21245] [http://hdl.handle.net/10807/25859]
Epigenetic silencing of SOCS3 identifies a subset of prostate cancer with an aggressive behavior
Pierconti, Francesco;Martini, Maurizio;Pinto, Francesco;Cenci, Tonia;Capodimonti, Sara;Calarco, Alessandro;Bassi, Pierfrancesco;Larocca, Luigi Maria
2011
Abstract
Chronic inflammation and subsequent tissutal alterations may play a key role in prostate carcinogenesis. In this way, molecular alterations of the suppressor of cytokine signaling 3 (SOCS3), one of the most important inhibitory molecule of inflammatory signal transduction circuitries, could contribute to explain the pleiotropic role of interleukin-6 (IL-6) in this type of cancer.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
