The purpose of this study was to investigate the ability of diffusion-weighted imaging (DWI) and the apparent diffusion coefficient (ADC) in the detection and characterisation of breast lesions. MATERIALS AND METHODS: From September 2005 to September 2007, 86 patients with breast lesions who underwent magnetic resonance imaging (MRI) in our department were included in our study. MRI was performed with a 1.5-T unit using a standard protocol including DWI sequence. For each breast lesion, the ADC value was calculated and compared with that of normal breast tissue and to the definitive pathological diagnosis. Mann-Whitney U and Kruskal-Wallis tests were used for statistical analysis. RESULTS: A total of 126 breast lesions were detected. Pathology results revealed 100 malignant and 26 benign lesions. Mean diameter of lesions was 26.02 mm (range 4-90 mm), including 52 lesions </=15 mm in size. Mean ADC value of normal glandular tissue was 1.55x10(-3) mm(2)/s. Mean ADC value of malignant lesions was 0.97x10(-3) mm(2)/s. Mean ADC value for benign lesions was 1.66x10(-3) mm(2)/s. Benign lesions showed ADC values significantly higher than malignant lesions (p<0.0001). CONCLUSIONS: DWI provides reliable information to support MRI diagnosis of breast masses. ADC value appears a promising adjunctive parameter in distinguishing malignant from benign breast lesions.

Belli, P., Costantini, M., Bufi, E., Magistrelli, A., La Torre, G., Bonomo, L., DIFFUSION-WEIGHTED IMAGING IN BREAST LESION EVALUATION, <<LA RADIOLOGIA MEDICA>>, 2010; 115 (Febbraio): 51-69 [http://hdl.handle.net/10807/25693]

DIFFUSION-WEIGHTED IMAGING IN BREAST LESION EVALUATION

Belli, Paolo;Costantini, Melania;Bufi, Enida;Magistrelli, Andrea;La Torre, Giuseppe;Bonomo, Lorenzo
2010

Abstract

The purpose of this study was to investigate the ability of diffusion-weighted imaging (DWI) and the apparent diffusion coefficient (ADC) in the detection and characterisation of breast lesions. MATERIALS AND METHODS: From September 2005 to September 2007, 86 patients with breast lesions who underwent magnetic resonance imaging (MRI) in our department were included in our study. MRI was performed with a 1.5-T unit using a standard protocol including DWI sequence. For each breast lesion, the ADC value was calculated and compared with that of normal breast tissue and to the definitive pathological diagnosis. Mann-Whitney U and Kruskal-Wallis tests were used for statistical analysis. RESULTS: A total of 126 breast lesions were detected. Pathology results revealed 100 malignant and 26 benign lesions. Mean diameter of lesions was 26.02 mm (range 4-90 mm), including 52 lesions
Inglese
Belli, P., Costantini, M., Bufi, E., Magistrelli, A., La Torre, G., Bonomo, L., DIFFUSION-WEIGHTED IMAGING IN BREAST LESION EVALUATION, <>, 2010; 115 (Febbraio): 51-69 [http://hdl.handle.net/10807/25693]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/25693
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