The primary structures of two salivary proline-rich peptides (PRP-SP-A, M 6156.0 amu and PRP-SP-B, M 1905.0 amu), from pig (Sus scrofa) were determined. The PRP-SP-B peptide, 21 residues long, overlaps with a sequence repeated 43 times in three deposited cDNAs coding for PRP proteins cloned from porcine parotid glands (Swiss-Prot codes: Q95JC9, Q95JD1, Q95JD0). PRP-SP-A peptide, 56 amino acid residues long, overlaps with the N-terminus repeats of Q95JC9 and Q95JD1 and it is phosphorylated at Ser 12 and 14. The two peptides were found both in whole saliva and in granules from pig parotid glands. The biosynthesis of the two peptides implies the action of a proteinase responsible for Pro down arrow Ala cleavage in the pre-secretory process. (c) 2005 Elsevier Inc. All rights reserved.

Patamia, M., Messana, I., Petruzzelli, R., Vitali, A., Inzitari, R., Cabras, T., Fanali, C., Scarano, E., Contucci, A. M., Galtieri, A., Castagnola, M., Two proline-rich peptides from pig (Sus scrofa) salivary glands generated by a pre-secretory pathway underlying the action of a proteinase cleaving Pro-Ala bonds, <<PEPTIDES>>, 2005; (26): 1550-1559 [http://hdl.handle.net/10807/25607]

Two proline-rich peptides from pig (Sus scrofa) salivary glands generated by a pre-secretory pathway underlying the action of a proteinase cleaving Pro-Ala bonds

Patamia, Maria;Messana, Irene;Vitali, Alberto;Inzitari, Rosanna;Cabras , Tiziana;Fanali, Chiara;Scarano, Emanuele;Contucci, Alessia Maria;Castagnola, Massimo
2005

Abstract

The primary structures of two salivary proline-rich peptides (PRP-SP-A, M 6156.0 amu and PRP-SP-B, M 1905.0 amu), from pig (Sus scrofa) were determined. The PRP-SP-B peptide, 21 residues long, overlaps with a sequence repeated 43 times in three deposited cDNAs coding for PRP proteins cloned from porcine parotid glands (Swiss-Prot codes: Q95JC9, Q95JD1, Q95JD0). PRP-SP-A peptide, 56 amino acid residues long, overlaps with the N-terminus repeats of Q95JC9 and Q95JD1 and it is phosphorylated at Ser 12 and 14. The two peptides were found both in whole saliva and in granules from pig parotid glands. The biosynthesis of the two peptides implies the action of a proteinase responsible for Pro down arrow Ala cleavage in the pre-secretory process. (c) 2005 Elsevier Inc. All rights reserved.
Inglese
Patamia, M., Messana, I., Petruzzelli, R., Vitali, A., Inzitari, R., Cabras, T., Fanali, C., Scarano, E., Contucci, A. M., Galtieri, A., Castagnola, M., Two proline-rich peptides from pig (Sus scrofa) salivary glands generated by a pre-secretory pathway underlying the action of a proteinase cleaving Pro-Ala bonds, <>, 2005; (26): 1550-1559 [http://hdl.handle.net/10807/25607]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/25607
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