Background. Treatment of patients with cardiac arrest includes basic and advanced life support (ALS) as outlined by the European Resuscitation Council. Until recently, there has been limited evidence to show that administration of these drugs improved patient outcomes. However, several randomized clinical trials testing various drugs during cardiac arrest have been published within the last years. Methods. We review these in this article. Results. Adrenergics have a small effect on survival after cardiac arrest, and survival rates in trials on ALS drugs are generally low. There is a continuing need for high-quality clinical trials to test new drugs to improve outcomes for patients with heart failure.
Andersen, L. W., Nolan, J. P., Sandroni, C., Drugs for advanced life support, <<INTENSIVE CARE MEDICINE>>, 2022; 48 (5): 606-608. [doi:10.1007/s00134-022-06678-1] [https://hdl.handle.net/10807/234524]
Drugs for advanced life support
Sandroni, Claudio
Ultimo
Writing – Original Draft Preparation
2022
Abstract
Background. Treatment of patients with cardiac arrest includes basic and advanced life support (ALS) as outlined by the European Resuscitation Council. Until recently, there has been limited evidence to show that administration of these drugs improved patient outcomes. However, several randomized clinical trials testing various drugs during cardiac arrest have been published within the last years. Methods. We review these in this article. Results. Adrenergics have a small effect on survival after cardiac arrest, and survival rates in trials on ALS drugs are generally low. There is a continuing need for high-quality clinical trials to test new drugs to improve outcomes for patients with heart failure.
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