Trauma-induced coagulopathy (TIC) is a clotting disorder resulting from severe tissue damage combined with haemorrhagic shock, resulting in an inability to form and maintain clots leading to excessive bleeding and worsening shock and spiralling into a vicious cycle. TIC is characterized by a shift from a hypocoagulable to a hypercoagulable profile, with a consequent increased risk of thromboembolic events and organ dysfunction. In patients with TIC, platelets are dysfunctional in their adhesion and aggregation capabilities, and platelet-leukocyte aggregates (PLAs) form during coagulation. A better understanding of the complex and time-dynamic pathophysiology of TIC may help reduce potentially preventable deaths due to trauma-induced shock.
Kleinveld, D. J. B., Hamada, S. R., Sandroni, C., Trauma-induced coagulopathy, <<INTENSIVE CARE MEDICINE>>, 2022; 48 (11): 1642-1645. [doi:10.1007/s00134-022-06834-7] [https://hdl.handle.net/10807/234518]
Trauma-induced coagulopathy
Sandroni, Claudio
Ultimo
Supervision
2022
Abstract
Trauma-induced coagulopathy (TIC) is a clotting disorder resulting from severe tissue damage combined with haemorrhagic shock, resulting in an inability to form and maintain clots leading to excessive bleeding and worsening shock and spiralling into a vicious cycle. TIC is characterized by a shift from a hypocoagulable to a hypercoagulable profile, with a consequent increased risk of thromboembolic events and organ dysfunction. In patients with TIC, platelets are dysfunctional in their adhesion and aggregation capabilities, and platelet-leukocyte aggregates (PLAs) form during coagulation. A better understanding of the complex and time-dynamic pathophysiology of TIC may help reduce potentially preventable deaths due to trauma-induced shock.
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