There are a few reported cases of isolated localized metastasis to bone arising from cancer of uterine cervix in the literature. This is a case of uterine cervix cancer with isolated metastasis to the humerus. A 57-year-old female with a diagnosis of FIGO Stage IIB invasive squamous cell carcinoma of uterine cervix underwent neoadjuvant chemoradiation therapy (CRT) and radical surgery with complete pathological response. Nine months after the surgery, a total body positron emission tomography/computed tomography (PET/CT) scan documented a lesion localized in the proximal part of the right humerus, whereas no evidence of skeletal metastasis found elsewhere. The biopsy from the bone lesion showed a metastatic squamous cell carcinoma of the uterine cervix. A surgical excision of the humeral lesion plus chemotherapy and zoledronic acid was performed. After 9 months, the patient experienced liver metastases and died 2 months later. Bone metastasis is not so infrequent in patients with locally advanced cervical cancer. Total body PET/CT scan should be included in staging work up, and an appropriate treatment should have the primary objective of quality of life preservation.

Gioe, A., Arciuolo, D., Carbone, M. V., Zannoni, G., Gambacorta, M. A., Maccauro, G., Scambia, G., Corrado, G., Isolated humeral metastasis in cervical cancer: A case report and review of the literature, <<JOURNAL OF CANCER RESEARCH AND THERAPEUTICS>>, 2022; 18 (1): 273-276. [doi:10.4103/jcrt.JCRT_9_20] [https://hdl.handle.net/10807/232753]

Isolated humeral metastasis in cervical cancer: A case report and review of the literature

Gioe, Alessandro;Arciuolo, Damiano;Carbone, Maria Vittoria;Gambacorta, Maria Antonietta;Maccauro, Giulio;Scambia, Giovanni;Corrado, Giacomo
2022

Abstract

There are a few reported cases of isolated localized metastasis to bone arising from cancer of uterine cervix in the literature. This is a case of uterine cervix cancer with isolated metastasis to the humerus. A 57-year-old female with a diagnosis of FIGO Stage IIB invasive squamous cell carcinoma of uterine cervix underwent neoadjuvant chemoradiation therapy (CRT) and radical surgery with complete pathological response. Nine months after the surgery, a total body positron emission tomography/computed tomography (PET/CT) scan documented a lesion localized in the proximal part of the right humerus, whereas no evidence of skeletal metastasis found elsewhere. The biopsy from the bone lesion showed a metastatic squamous cell carcinoma of the uterine cervix. A surgical excision of the humeral lesion plus chemotherapy and zoledronic acid was performed. After 9 months, the patient experienced liver metastases and died 2 months later. Bone metastasis is not so infrequent in patients with locally advanced cervical cancer. Total body PET/CT scan should be included in staging work up, and an appropriate treatment should have the primary objective of quality of life preservation.
2022
Inglese
Gioe, A., Arciuolo, D., Carbone, M. V., Zannoni, G., Gambacorta, M. A., Maccauro, G., Scambia, G., Corrado, G., Isolated humeral metastasis in cervical cancer: A case report and review of the literature, <<JOURNAL OF CANCER RESEARCH AND THERAPEUTICS>>, 2022; 18 (1): 273-276. [doi:10.4103/jcrt.JCRT_9_20] [https://hdl.handle.net/10807/232753]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/232753
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