This study explores the photoprotective effects of rutin, a bioflavonoid found in some vegetables and fruits, against UVA-induced damage in human skin fibroblasts. Our results show that rutin increases cell viability and reduces the high levels of ROS generated by photo-oxidative stress (1 and 2 h of UVA exposure). These effects are related to rutin’s ability to modulate the Nrf2 transcriptional pathway. Interestingly, activation of the Nrf2 signaling pathway results in an increase in reduced glutathione and Bcl2/Bax ratio, and the subsequent protection of mitochondrial respiratory capacity. These results demonstrate how rutin may play a potentially cytoprotective role against UVA-induced skin damage through a purely antiapoptotic mechanism.
Tabolacci, E., Tringali, G., Nobile, V., Duca, S., Pizzoferrato, M., Bottoni, P., Clementi, M. E., Rutin Protects Fibroblasts from UVA Radiation through Stimulation of Nrf2 Pathway., <<ANTIOXIDANTS>>, 2023; (12(4)): 820-835. [doi:10.3390/antiox12040820] [https://hdl.handle.net/10807/230772]
Rutin Protects Fibroblasts from UVA Radiation through Stimulation of Nrf2 Pathway.
Tabolacci, Elisabetta;Tringali, Giuseppe;Nobile, Veronica;Duca, Sara;Pizzoferrato, Michela;Clementi, Maria Elisabetta
2023
Abstract
This study explores the photoprotective effects of rutin, a bioflavonoid found in some vegetables and fruits, against UVA-induced damage in human skin fibroblasts. Our results show that rutin increases cell viability and reduces the high levels of ROS generated by photo-oxidative stress (1 and 2 h of UVA exposure). These effects are related to rutin’s ability to modulate the Nrf2 transcriptional pathway. Interestingly, activation of the Nrf2 signaling pathway results in an increase in reduced glutathione and Bcl2/Bax ratio, and the subsequent protection of mitochondrial respiratory capacity. These results demonstrate how rutin may play a potentially cytoprotective role against UVA-induced skin damage through a purely antiapoptotic mechanism.File | Dimensione | Formato | |
---|---|---|---|
antioxidants-12-00820-v2.pdf
accesso aperto
Tipologia file ?:
Versione Editoriale (PDF)
Licenza:
Creative commons
Dimensione
2.4 MB
Formato
Adobe PDF
|
2.4 MB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.