Grimsholm et al. show that CD27dull and CD27bright represent sequential MBC developmental stages. T cell- and germinal center (GC)-independent CD27dull MBCs are the plastic source of strongly selected and GC-dependent CD27bright MBCs. CD27dull MBCs, able to expand and differentiate in response to change, ensure stability and flexibility of human B cell memory.

Grimsholm, O., Piano Mortari, E., Davydov, A. N., Shugay, M., Obraztsova, A. S., Bocci, C., Marasco, E., Marcellini, V., Aranburu, A., Farroni, C., Silvestris, D. A., Cristofoletti, C., Giorda, E., Scarsella, M., Cascioli, S., Barresi, S., Lougaris, V., Plebani, A., Cancrini, C., Finocchi, A., Moschese, V., Valentini, D., Vallone, C., Signore, F., De Vincentiis, G., Zaffina, S., Russo, G., Gallo, A., Locatelli, F., Tozzi, A. E., Tartaglia, M., Chudakov, D. M., Carsetti, R., The Interplay between CD27dull and CD27bright B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory, <<CELL REPORTS>>, 2020; 30 (9): 2963-2977. [doi:10.1016/j.celrep.2020.02.022] [https://hdl.handle.net/10807/229748]

The Interplay between CD27dull and CD27bright B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory

Locatelli, Franco
Writing – Review & Editing
;
2020

Abstract

Grimsholm et al. show that CD27dull and CD27bright represent sequential MBC developmental stages. T cell- and germinal center (GC)-independent CD27dull MBCs are the plastic source of strongly selected and GC-dependent CD27bright MBCs. CD27dull MBCs, able to expand and differentiate in response to change, ensure stability and flexibility of human B cell memory.
2020
Inglese
Grimsholm, O., Piano Mortari, E., Davydov, A. N., Shugay, M., Obraztsova, A. S., Bocci, C., Marasco, E., Marcellini, V., Aranburu, A., Farroni, C., Silvestris, D. A., Cristofoletti, C., Giorda, E., Scarsella, M., Cascioli, S., Barresi, S., Lougaris, V., Plebani, A., Cancrini, C., Finocchi, A., Moschese, V., Valentini, D., Vallone, C., Signore, F., De Vincentiis, G., Zaffina, S., Russo, G., Gallo, A., Locatelli, F., Tozzi, A. E., Tartaglia, M., Chudakov, D. M., Carsetti, R., The Interplay between CD27dull and CD27bright B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory, <<CELL REPORTS>>, 2020; 30 (9): 2963-2977. [doi:10.1016/j.celrep.2020.02.022] [https://hdl.handle.net/10807/229748]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/229748
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