Treatment with activated protein C has been shown to reduce mortality in adult patients with severe sepsis but also to increase risk of bleeding. In patients with predisposition to bleeding, as in preterm infants, the inactivated form of protein C could serve as a safe therapeutic option. We report the case of a preterm neonate who developed severe sepsis on the 28th day of life, who was successfully treated with the inactivated form of protein C for a period of 96 hours.

De Carolis, M. P., Polimeni, V., Papacci, P., Lacerenza, S., Romagnoli, C., Severe sepsis in a premature neoante: protein C replacemnet therapy, <<THE JOURNAL OF PEDIATRICS>>, 2008; (50): 405-408 [http://hdl.handle.net/10807/22906]

Severe sepsis in a premature neoante: protein C replacemnet therapy

De Carolis;Maria Pia; Polimeni;Valentina; Papacci;Patrizia; Lacerenza;Serafina; Romagnoli
2008

Abstract

Treatment with activated protein C has been shown to reduce mortality in adult patients with severe sepsis but also to increase risk of bleeding. In patients with predisposition to bleeding, as in preterm infants, the inactivated form of protein C could serve as a safe therapeutic option. We report the case of a preterm neonate who developed severe sepsis on the 28th day of life, who was successfully treated with the inactivated form of protein C for a period of 96 hours.
Inglese
De Carolis, M. P., Polimeni, V., Papacci, P., Lacerenza, S., Romagnoli, C., Severe sepsis in a premature neoante: protein C replacemnet therapy, <<THE JOURNAL OF PEDIATRICS>>, 2008; (50): 405-408 [http://hdl.handle.net/10807/22906]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/22906
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