ObjectivesOral lichen planus with exclusive keratotic reticular, papular, and/or plaque-like lesions (K-OLP) is a clinical pattern of OLP that may be associated with a complex symptomatology and psychological alteration. The aim of the study was to evaluate the prevalence of anxiety (A) and depression (D) in patients with K-OLP, analyzing the potential predictors which can affect mental health status.MethodsThree hundred K-OLP patients versus 300 healthy controls (HC) were recruited in 15 Italian universities. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), and Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A) were administered.ResultsThe K-OLP patients showed statistically higher scores in the NRS, T-PRI, HAM-D, and HAM-A compared with the HC (p-value < 0.001*). A and D were found in 158 (52.7%) and 148 (49.3%) K-OLP patients. Strong linear correlations were identified between HAM-A, HAM-D, NRS, T-PRI, and employment status and between HAM-D, HAM-A, NRS, T-PRI, employment status, and female gender. Multivariate logistic regression revealed that HAM-D and HAM-A showed the greatest increase in the R2 value for A and D in the K-OLP patients, respectively (DR2 = 55.5% p-value < 0.001**; DR2 = 56.5% p-value < 0.001**).ConclusionsThe prevalence of A and D is higher in the K-OLP patients compared with the HC, also found in K-OLP subjects without pain, suggesting that the processing of pain may be in a certain way independent of the processing of mood.
Adamo, D., Calabria, E., Canfora, F., Coppola, N., Leuci, S., Mignogna, M., Muzio, L. L., Spirito, F., Giuliani, M., Azzi, L., Dani, M., Colella, G., Colella, C., Montebugnoli, L., Gissi, D. B., Gabriele, M., Nisi, M., Sardella, A., Lodi, G., Varoni, E. M., Giudice, A., Antonelli, A., Gambino, A., Antonucci, G., Vescovi, P., Meleti, M., Majorana, A., Bardellini, E., Campisi, G., Panzarella, V., Spadari, F., Garagiola, U., Pentenero, M., Sutera, S., Biasotto, M., Ottaviani, G., Gobbo, M., Nardini, L. G., Romeo, U., Tenore, G., Serpico, R., Lucchese, A., Lajolo, C., Gioco, G., Aria, M., D'Aniello, L., Mignogna, M. D., Anxiety and depression in keratotic oral lichen planus: a multicentric study from the SIPMO, <<CLINICAL ORAL INVESTIGATIONS>>, 2023; (N/A): N/A-N/A. [doi:10.1007/s00784-023-04909-3] [https://hdl.handle.net/10807/228929]
Anxiety and depression in keratotic oral lichen planus: a multicentric study from the SIPMO
Giuliani, Michele;Lajolo, Carlo;Gioco, Gioele;
2023
Abstract
ObjectivesOral lichen planus with exclusive keratotic reticular, papular, and/or plaque-like lesions (K-OLP) is a clinical pattern of OLP that may be associated with a complex symptomatology and psychological alteration. The aim of the study was to evaluate the prevalence of anxiety (A) and depression (D) in patients with K-OLP, analyzing the potential predictors which can affect mental health status.MethodsThree hundred K-OLP patients versus 300 healthy controls (HC) were recruited in 15 Italian universities. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), and Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A) were administered.ResultsThe K-OLP patients showed statistically higher scores in the NRS, T-PRI, HAM-D, and HAM-A compared with the HC (p-value < 0.001*). A and D were found in 158 (52.7%) and 148 (49.3%) K-OLP patients. Strong linear correlations were identified between HAM-A, HAM-D, NRS, T-PRI, and employment status and between HAM-D, HAM-A, NRS, T-PRI, employment status, and female gender. Multivariate logistic regression revealed that HAM-D and HAM-A showed the greatest increase in the R2 value for A and D in the K-OLP patients, respectively (DR2 = 55.5% p-value < 0.001**; DR2 = 56.5% p-value < 0.001**).ConclusionsThe prevalence of A and D is higher in the K-OLP patients compared with the HC, also found in K-OLP subjects without pain, suggesting that the processing of pain may be in a certain way independent of the processing of mood.
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