In the natural history of SARS-CoV-2 infection, liver injury is frequent but quite mild and it is defined as any liver damage occurring during disease progression and treatment of infection in patients with or without pre-existing liver diseases. The underlying mechanisms for hepatic injury in patients with COVID-19 are still unclear but the liver damage in SARS-CoV-2 infection seems to be directly caused by virus-induced cytopathic effects. In this review, we will summarize all data of updated literature, regarding the relationship between SARS-CoV-2 infection, acute response and liver involvement. An overview will be given on liver injury, liver transplant and the possible consequences of COVID-19 in patients with pre-existing liver diseases.
Napodano, C., Pocino, K., Stefanile, A., Marino, M., Miele, L., Gulli, F., Basile, V., Pandolfi, F., Gasbarrini, A., Rapaccini, G. L., Basile, U., COVID-19 and hepatic involvement: The liver as a main actor of the pandemic novel, <<SCANDINAVIAN JOURNAL OF IMMUNOLOGY>>, 2021; 93 (3): e12977-N/A. [doi:10.1111/sji.12977] [https://hdl.handle.net/10807/220216]
COVID-19 and hepatic involvement: The liver as a main actor of the pandemic novel
Napodano, Cecilia;Pocino, Krizia;Marino, Mariapaola;Miele, Luca;Pandolfi, Franco;Gasbarrini, Antonio;Rapaccini, Gian Ludovico;Basile, Umberto
2021
Abstract
In the natural history of SARS-CoV-2 infection, liver injury is frequent but quite mild and it is defined as any liver damage occurring during disease progression and treatment of infection in patients with or without pre-existing liver diseases. The underlying mechanisms for hepatic injury in patients with COVID-19 are still unclear but the liver damage in SARS-CoV-2 infection seems to be directly caused by virus-induced cytopathic effects. In this review, we will summarize all data of updated literature, regarding the relationship between SARS-CoV-2 infection, acute response and liver involvement. An overview will be given on liver injury, liver transplant and the possible consequences of COVID-19 in patients with pre-existing liver diseases.
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