Non-alcoholic fatty liver disease (NAFLD) is a multi-faceted disorder, which ranges from simple steatosis to non-alcoholic steatohepatitis (NASH) with/without fibrosis. The effects of specific risk factors, such as obesity and sedentary lifestyle, on predisposing genetic settings eventually lead to the development of NAFLD in children. The complex interplay between genes and environment in NAFLD pathogenesis is sustained by multiple mechanisms that involve liver crosstalk with other organs and tissues, especially gut and adipose tissue. Unfortunately, natural history of paediatric NAFLD is lacking, and the etiopathogenesis is still in the process of being defined. Potential early predictors and suitable non-invasive diagnostic tools can be discovered based on the pathogenetic mechanisms and histological patterns. This will also help design novel treatments and a comprehensive and successful management strategy for patients. In this review, we discuss the recent advances made in genetics, etiopathogenesis, diagnosis, and therapeutic management of NAFLD, focusing especially on the obesity-related steatotic liver condition. © 2013 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

Nobili, V., Svegliati-Baroni, G., Alisi, A., Miele, L., Valenti, L., Vajro, P., A 360-degree overview of paediatric NAFLD: Recent insights, <<JOURNAL OF HEPATOLOGY>>, 2013; 58 (6): 1218-1229. [doi:10.1016/j.jhep.2012.12.003] [https://hdl.handle.net/10807/219670]

A 360-degree overview of paediatric NAFLD: Recent insights

Nobili, Valerio;Miele, Luca;
2013

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a multi-faceted disorder, which ranges from simple steatosis to non-alcoholic steatohepatitis (NASH) with/without fibrosis. The effects of specific risk factors, such as obesity and sedentary lifestyle, on predisposing genetic settings eventually lead to the development of NAFLD in children. The complex interplay between genes and environment in NAFLD pathogenesis is sustained by multiple mechanisms that involve liver crosstalk with other organs and tissues, especially gut and adipose tissue. Unfortunately, natural history of paediatric NAFLD is lacking, and the etiopathogenesis is still in the process of being defined. Potential early predictors and suitable non-invasive diagnostic tools can be discovered based on the pathogenetic mechanisms and histological patterns. This will also help design novel treatments and a comprehensive and successful management strategy for patients. In this review, we discuss the recent advances made in genetics, etiopathogenesis, diagnosis, and therapeutic management of NAFLD, focusing especially on the obesity-related steatotic liver condition. © 2013 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Inglese
Nobili, V., Svegliati-Baroni, G., Alisi, A., Miele, L., Valenti, L., Vajro, P., A 360-degree overview of paediatric NAFLD: Recent insights, <<JOURNAL OF HEPATOLOGY>>, 2013; 58 (6): 1218-1229. [doi:10.1016/j.jhep.2012.12.003] [https://hdl.handle.net/10807/219670]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/219670
Citazioni
  • ???jsp.display-item.citation.pmc??? 54
  • Scopus 132
  • ???jsp.display-item.citation.isi??? 123
social impact