Neurosarcoidosis is an uncommon and multiform clinical entity. Its presentation as an isolated longitudinal extensive transverse myelitis (LETM) is rare and challenging to identify. We report a case of LETM in a 60-year-old patient with no significant systemic symptoms nor relevant medical history. The peculiar spinal magnetic resonance imaging finding characterized by a posterior and central canal subpial contrast enhancement, the so-called "trident sign," together with chest computed tomography scan and lymph node biopsy led to the diagnosis of sarcoidosis. We also discuss the main differential diagnoses of LETM and therapeutic options for sarcoidosis-related myelitis.

Cicia, A., Nociti, V., Bianco, A., De Fino, C., Carlomagno, V., Mirabella, M., Lucchini, M., Neurosarcoidosis presenting as longitudinally extensive myelitis: Diagnostic assessment, differential diagnosis, and therapeutic approach, <<TRANSLATIONAL NEUROSCIENCE>>, 2022; 13 (1): 191-197. [doi:10.1515/tnsci-2022-0231] [http://hdl.handle.net/10807/214486]

Neurosarcoidosis presenting as longitudinally extensive myelitis: Diagnostic assessment, differential diagnosis, and therapeutic approach

Cicia, Alessandra;Nociti, Viviana;Bianco, Assunta;De Fino, Chiara;Carlomagno, Vincenzo;Mirabella, Massimiliano
;
Lucchini, Matteo
2022

Abstract

Neurosarcoidosis is an uncommon and multiform clinical entity. Its presentation as an isolated longitudinal extensive transverse myelitis (LETM) is rare and challenging to identify. We report a case of LETM in a 60-year-old patient with no significant systemic symptoms nor relevant medical history. The peculiar spinal magnetic resonance imaging finding characterized by a posterior and central canal subpial contrast enhancement, the so-called "trident sign," together with chest computed tomography scan and lymph node biopsy led to the diagnosis of sarcoidosis. We also discuss the main differential diagnoses of LETM and therapeutic options for sarcoidosis-related myelitis.
Inglese
Cicia, A., Nociti, V., Bianco, A., De Fino, C., Carlomagno, V., Mirabella, M., Lucchini, M., Neurosarcoidosis presenting as longitudinally extensive myelitis: Diagnostic assessment, differential diagnosis, and therapeutic approach, <<TRANSLATIONAL NEUROSCIENCE>>, 2022; 13 (1): 191-197. [doi:10.1515/tnsci-2022-0231] [http://hdl.handle.net/10807/214486]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/214486
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact