Background: Anti NMDA receptor (anti NMDAR) encephalitis is a well-characterized entity in children associating movement disorders, psychiatric features and speech difficulties. Novel phenotypes have been described in adults.Methods and Results: A 4-year-old girl presented partial seizures which evolved towards sudden and isolated Broca's aphasia. Anti NMDAR antibodies were positive in CSF and serum confirming anti NMDAR encephalitis. Clinical recovery was observed after a specific treatment.Conclusion: This case widens the clinical spectrum of anti-NMDAR encephalitis in children and awareness of this newly identified symptom is important as early treatment is a predictor of good outcome (C) 2014 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

Deiva, K., Pera, M. C., Maurey, H., Chrétien, P., Archambaud, F., Bouilleret, V., Tardieu, M., Sudden and isolated Broca's aphasia: a new clinical phenotype of anti NMDA receptor antibodies encephalitis in children, <<EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY>>, 2014; 18 (6): 790-792. [doi:10.1016/j.ejpn.2014.06.002] [http://hdl.handle.net/10807/213570]

Sudden and isolated Broca's aphasia: a new clinical phenotype of anti NMDA receptor antibodies encephalitis in children

Pera, Maria Carmela;
2014

Abstract

Background: Anti NMDA receptor (anti NMDAR) encephalitis is a well-characterized entity in children associating movement disorders, psychiatric features and speech difficulties. Novel phenotypes have been described in adults.Methods and Results: A 4-year-old girl presented partial seizures which evolved towards sudden and isolated Broca's aphasia. Anti NMDAR antibodies were positive in CSF and serum confirming anti NMDAR encephalitis. Clinical recovery was observed after a specific treatment.Conclusion: This case widens the clinical spectrum of anti-NMDAR encephalitis in children and awareness of this newly identified symptom is important as early treatment is a predictor of good outcome (C) 2014 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
Inglese
Deiva, K., Pera, M. C., Maurey, H., Chrétien, P., Archambaud, F., Bouilleret, V., Tardieu, M., Sudden and isolated Broca's aphasia: a new clinical phenotype of anti NMDA receptor antibodies encephalitis in children, <<EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY>>, 2014; 18 (6): 790-792. [doi:10.1016/j.ejpn.2014.06.002] [http://hdl.handle.net/10807/213570]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/213570
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