Objectives To assess clinical and cardiac magnetic resonance (CMR) imaging features of patients with peri-myocarditis following Coronavirus Disease 2019 (COVID-19) vaccination. Methods We retrospectively collected a case series of 27 patients who underwent CMR in the clinical suspect of heart inflammation following COVID-19 vaccination, from 16 large tertiary centers. Our patient's cohort was relatively young (36.6 +/- 16.8 years), predominately included males (n = 25/27) with few comorbidities and covered a catchment area of approximately 8 million vaccinated patients. Results CMR revealed typical mid-subepicardial non-ischemic late gadolinium enhancement (LGE) in 23 cases and matched positively with CMR T2 criteria of myocarditis. In 7 cases, typical hallmarks of acute pericarditis were present. Short-term follow-up (median = 20 days) from presentation was uneventful for 25/27 patients and unavailable in two cases. Conclusions While establishing a causal relationship between peri-myocardial inflammation and vaccine administration can be challenging, our clinical experience suggests that CMR should be performed for diagnosis confirmation and to drive clinical decision-making and follow-up.

Di Dedda, E. A., Barison, A., Aquaro, G. D., Ismail, T. F., Hua, A., Mantini, C., Ricci, F., Pontone, G., Volpe, A., Secchi, F., Di Renzi, P., Lovato, L., Niro, F., Liguori, C., De Biase, C., Monti, L., Cirò, A., Marano, R., Natale, L., Moliterno, E., Esposito, A., Vignale, D., Faletti, R., Gatti, M., Porcu, M., Saba, L., Chimenti, C., Galea, N., Francone, M., Cardiac magnetic resonance imaging of myocarditis and pericarditis following COVID-19 vaccination: a multicenter collection of 27 cases, <<EUROPEAN RADIOLOGY>>, 1; 32 (7): 4352-4360. [doi:10.1007/s00330-022-08566-0] [http://hdl.handle.net/10807/212946]

Cardiac magnetic resonance imaging of myocarditis and pericarditis following COVID-19 vaccination: a multicenter collection of 27 cases

Marano, Riccardo;Natale, Luigi;Moliterno, Eleonora;
2022

Abstract

Objectives To assess clinical and cardiac magnetic resonance (CMR) imaging features of patients with peri-myocarditis following Coronavirus Disease 2019 (COVID-19) vaccination. Methods We retrospectively collected a case series of 27 patients who underwent CMR in the clinical suspect of heart inflammation following COVID-19 vaccination, from 16 large tertiary centers. Our patient's cohort was relatively young (36.6 +/- 16.8 years), predominately included males (n = 25/27) with few comorbidities and covered a catchment area of approximately 8 million vaccinated patients. Results CMR revealed typical mid-subepicardial non-ischemic late gadolinium enhancement (LGE) in 23 cases and matched positively with CMR T2 criteria of myocarditis. In 7 cases, typical hallmarks of acute pericarditis were present. Short-term follow-up (median = 20 days) from presentation was uneventful for 25/27 patients and unavailable in two cases. Conclusions While establishing a causal relationship between peri-myocardial inflammation and vaccine administration can be challenging, our clinical experience suggests that CMR should be performed for diagnosis confirmation and to drive clinical decision-making and follow-up.
Inglese
Di Dedda, E. A., Barison, A., Aquaro, G. D., Ismail, T. F., Hua, A., Mantini, C., Ricci, F., Pontone, G., Volpe, A., Secchi, F., Di Renzi, P., Lovato, L., Niro, F., Liguori, C., De Biase, C., Monti, L., Cirò, A., Marano, R., Natale, L., Moliterno, E., Esposito, A., Vignale, D., Faletti, R., Gatti, M., Porcu, M., Saba, L., Chimenti, C., Galea, N., Francone, M., Cardiac magnetic resonance imaging of myocarditis and pericarditis following COVID-19 vaccination: a multicenter collection of 27 cases, <>, 1; 32 (7): 4352-4360. [doi:10.1007/s00330-022-08566-0] [http://hdl.handle.net/10807/212946]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/212946
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