The innate immune system is critically involved in the pathogenesis of familial Mediterranean fever (FMF), characterized by dysregulated inflammasome activity and recurrent inflammatory attacks: this is the most common among monogenic autoinflammatory diseases, which shares some biochemical pathways with the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection. In this short review we explore the overlap in the pathophysiology of FMF and SARS-CoV-2 infection, discussing how to understand better the interaction between the two diseases and optimize management. A poorer outcome of SARS-CoV-2 infection seems not to be present in infected FMF patients in terms of hospitalization time, need for oxygen support, need for intensive care, rate of complications and exitus. Long-term surveillance will confirm the relatively low risk of a worse prognosis observed so far in SARS-CoV-2-infected people with FMF. In these patients COVID-19 vaccines are recommended and their safety profile is expected to be similar to the general population.

Marinelli, F., Caporilli, C., Titolo, A., Rigante, D., Esposito, S., Clinical impact and disease evolution of SARS-CoV-2 infection in familial Mediterranean fever, <<PHARMACOLOGICAL RESEARCH>>, 106293; 2022 (182): 1-6. [doi:10.1016/j.phrs.2022.106293] [http://hdl.handle.net/10807/211282]

Clinical impact and disease evolution of SARS-CoV-2 infection in familial Mediterranean fever

Rigante, D;
2022

Abstract

The innate immune system is critically involved in the pathogenesis of familial Mediterranean fever (FMF), characterized by dysregulated inflammasome activity and recurrent inflammatory attacks: this is the most common among monogenic autoinflammatory diseases, which shares some biochemical pathways with the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection. In this short review we explore the overlap in the pathophysiology of FMF and SARS-CoV-2 infection, discussing how to understand better the interaction between the two diseases and optimize management. A poorer outcome of SARS-CoV-2 infection seems not to be present in infected FMF patients in terms of hospitalization time, need for oxygen support, need for intensive care, rate of complications and exitus. Long-term surveillance will confirm the relatively low risk of a worse prognosis observed so far in SARS-CoV-2-infected people with FMF. In these patients COVID-19 vaccines are recommended and their safety profile is expected to be similar to the general population.
Inglese
Marinelli, F., Caporilli, C., Titolo, A., Rigante, D., Esposito, S., Clinical impact and disease evolution of SARS-CoV-2 infection in familial Mediterranean fever, <<PHARMACOLOGICAL RESEARCH>>, 106293; 2022 (182): 1-6. [doi:10.1016/j.phrs.2022.106293] [http://hdl.handle.net/10807/211282]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/211282
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