The treatment of recurrent high-grade gliomas remains a major challenge of daily neuro-oncology practice, and imaging findings of new therapies may be challenging. Regorafenib is a multi-kinase inhibitor that has recently been introduced into clinical practice to treat recurrent glioblastoma, bringing with it a novel panel of MRI imaging findings. On the basis of the few data in the literature and on our personal experience, we have identified the main MRI changes during regorafenib therapy, and then, we defined two different patterns, trying to create a simple summary line of the main changes of pathological tissue during therapy. We named these patterns, respectively, pattern A (less frequent, similar to classical progression disease) and pattern B (more frequent, with decreased diffusivity and decrease contrast-enhancement). We have also reported MR changes concerning signal intensity on T1-weighted and T2-weighted images, SWI, and perfusion imaging, derived from the literature (small series or case reports) and from our clinical experience. The clinical implication of these imaging modifications remains to be defined, taking into account that we are still at the dawn in the evaluation of such imaging modifications

Gaudino, S., Marziali, G., Giordano, C., Gigli, R., Varcasia, G., Magnani, F., Chiesa, S., Balducci, M., Costantini, A. M., Della Pepa, G. M., Olivi, A., Russo, R., Colosimo, C., Regorafenib in Glioblastoma Recurrence: How to Deal With MR Imaging Treatments Changes, <<FRONTIERS IN RADIOLOGY>>, 2022; Feb 2022 (N/A): 1-7. [doi:10.3389/fradi.2021.790456] [http://hdl.handle.net/10807/201316]

Regorafenib in Glioblastoma Recurrence: How to Deal With MR Imaging Treatments Changes

Gaudino, Simona
Primo
Conceptualization
;
Giordano, Carolina
Secondo
;
Gigli, Riccardo;Varcasia, Giuseppe;Magnani, Francesca;Chiesa, Silvia;Balducci, Mario;Costantini, Alessandro Maria;Della Pepa, Giuseppe Maria;Olivi, Alessandro;Russo, Rosellina;Colosimo, Cesare
Ultimo
Supervision
2022

Abstract

The treatment of recurrent high-grade gliomas remains a major challenge of daily neuro-oncology practice, and imaging findings of new therapies may be challenging. Regorafenib is a multi-kinase inhibitor that has recently been introduced into clinical practice to treat recurrent glioblastoma, bringing with it a novel panel of MRI imaging findings. On the basis of the few data in the literature and on our personal experience, we have identified the main MRI changes during regorafenib therapy, and then, we defined two different patterns, trying to create a simple summary line of the main changes of pathological tissue during therapy. We named these patterns, respectively, pattern A (less frequent, similar to classical progression disease) and pattern B (more frequent, with decreased diffusivity and decrease contrast-enhancement). We have also reported MR changes concerning signal intensity on T1-weighted and T2-weighted images, SWI, and perfusion imaging, derived from the literature (small series or case reports) and from our clinical experience. The clinical implication of these imaging modifications remains to be defined, taking into account that we are still at the dawn in the evaluation of such imaging modifications
Inglese
Gaudino, S., Marziali, G., Giordano, C., Gigli, R., Varcasia, G., Magnani, F., Chiesa, S., Balducci, M., Costantini, A. M., Della Pepa, G. M., Olivi, A., Russo, R., Colosimo, C., Regorafenib in Glioblastoma Recurrence: How to Deal With MR Imaging Treatments Changes, <<FRONTIERS IN RADIOLOGY>>, 2022; Feb 2022 (N/A): 1-7. [doi:10.3389/fradi.2021.790456] [http://hdl.handle.net/10807/201316]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/201316
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