BaCKGroUNd: Non-melanoma skin cancers (NmSC) are the most common epithelial malignancies in organ transplantation recipients (otrs). in italy, incidence rates of post-transplantation NmSC are approximately 5% after 5 years and 10% after 10 years since organ transplantation. the objective was to describe risk factors associated with NmSC in a cohort of renal and liver transplant recipients, in a single-center longitudinal study. metHodS: renal and liver transplant patients, who underwent transplantation between June 1985 and december 2015, were visited for the first time or followed-up in a dedicated outpatient clinic every six months until July 2016. reSUltS: We included 356 renal and 76 liver transplant patients. 108 otrs (25.6%) presented 299 NmSC. 74 patients developed actinic keratosis (17.1%), 36 patients squamous cell carcinoma (8.5%), and 52 patients basal cell carcinoma (12.3%). time from transplantation and kidney transplant were the main risk factors for NmSC. Higher incidences of all NmSC were observed in patients >60 years, males and smokers, while decreased incidences were detected in individuals with higher educational levels. Multiple logistic regression models confirmed that male gender (rr 3.3, P=0.001), cigarette smoking (rr 2.0, P=0.026), light eye color (rr 2.9, P=0.001) and family history of cancer (rr 1.8, P=0.042) were independently associated with NmSC. CoNClUSioNS: dermatological follow-up is important in otrs, due to the higher risk of tumors and mainly NmSC. Clinical and environmental factors, including cigarette smoking, are useful in characterizing otr with higher risk of NmSC.

Fania, L., Abeni, D., Esposito, I., Spagnoletti, G., Citterio, F., Romagnoli, J., Castriota, M., Ricci, F., Moro, F., Perino, F., Mazzanti, C., De Simone, C., Peris, K., Behavioral and demographic factors associated with occurrence of non-melanoma skin cancer in organ transplant recipients, <<GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA>>, 2020; 155 (5): 669-675. [doi:10.23736/S0392-0488.18.06099-6] [http://hdl.handle.net/10807/197922]

Behavioral and demographic factors associated with occurrence of non-melanoma skin cancer in organ transplant recipients

Spagnoletti, G.;Romagnoli, J.;Moro, F.;Perino, F.;de Simone, C.;Peris, K.
2020

Abstract

BaCKGroUNd: Non-melanoma skin cancers (NmSC) are the most common epithelial malignancies in organ transplantation recipients (otrs). in italy, incidence rates of post-transplantation NmSC are approximately 5% after 5 years and 10% after 10 years since organ transplantation. the objective was to describe risk factors associated with NmSC in a cohort of renal and liver transplant recipients, in a single-center longitudinal study. metHodS: renal and liver transplant patients, who underwent transplantation between June 1985 and december 2015, were visited for the first time or followed-up in a dedicated outpatient clinic every six months until July 2016. reSUltS: We included 356 renal and 76 liver transplant patients. 108 otrs (25.6%) presented 299 NmSC. 74 patients developed actinic keratosis (17.1%), 36 patients squamous cell carcinoma (8.5%), and 52 patients basal cell carcinoma (12.3%). time from transplantation and kidney transplant were the main risk factors for NmSC. Higher incidences of all NmSC were observed in patients >60 years, males and smokers, while decreased incidences were detected in individuals with higher educational levels. Multiple logistic regression models confirmed that male gender (rr 3.3, P=0.001), cigarette smoking (rr 2.0, P=0.026), light eye color (rr 2.9, P=0.001) and family history of cancer (rr 1.8, P=0.042) were independently associated with NmSC. CoNClUSioNS: dermatological follow-up is important in otrs, due to the higher risk of tumors and mainly NmSC. Clinical and environmental factors, including cigarette smoking, are useful in characterizing otr with higher risk of NmSC.
Inglese
Fania, L., Abeni, D., Esposito, I., Spagnoletti, G., Citterio, F., Romagnoli, J., Castriota, M., Ricci, F., Moro, F., Perino, F., Mazzanti, C., De Simone, C., Peris, K., Behavioral and demographic factors associated with occurrence of non-melanoma skin cancer in organ transplant recipients, <<GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA>>, 2020; 155 (5): 669-675. [doi:10.23736/S0392-0488.18.06099-6] [http://hdl.handle.net/10807/197922]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/197922
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