A facile microwave assisted three-component protocol allows the synthesis of chiral aryl-1,2-mercaptoamines in water in a few minutes with high yields, bypassing the use of toxic aziridine intermediates. The chiral 1,2-mercaptoamines were then deracemized through enzymatic resolution of the racemates using monoamine oxidase (MAO-N) biocatalysts.
Lauder, K., Masci, D., Toscani, A., Al Mekdad, A., Black, G. W., Brown, N. L., Turner, N. J., Luisi, R., Castagnolo, D., A facile and regioselective multicomponent synthesis of chiral aryl-1,2-mercaptoamines in water followed by monoamine oxidase (MAO-N) enzymatic resolution, <<ORGANIC & BIOMOLECULAR CHEMISTRY>>, 2019; 17 (40): 8982-8986. [doi:10.1039/c9ob01962f] [http://hdl.handle.net/10807/195388]
A facile and regioselective multicomponent synthesis of chiral aryl-1,2-mercaptoamines in water followed by monoamine oxidase (MAO-N) enzymatic resolution
Masci, DomizianaSecondo
Writing – Review & Editing
;
2019
Abstract
A facile microwave assisted three-component protocol allows the synthesis of chiral aryl-1,2-mercaptoamines in water in a few minutes with high yields, bypassing the use of toxic aziridine intermediates. The chiral 1,2-mercaptoamines were then deracemized through enzymatic resolution of the racemates using monoamine oxidase (MAO-N) biocatalysts.
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