Multiple sclerosis (MS) and celiac disease (CD) are considered to be T-cell-mediated autoimmune diseases. We describe a woman affected by a relapsing-remitting demyelinating disease of the central nervous system and occult CD (MS-CD), who showed during neurologic exacerbations a strong increased expression of T-bet, the key transcription factor for the development of Th1 cells, in circulating T, B cells and monocytes. Conversely, no difference of T-bet expression was observed in B cells from relapsing-remitting MS patients, either in relapse or in remission, and in controls. In the MS-CD patient, the interaction between MS- and CD-related inflammatory processes may result in an amplification of Th1 immune response

Frisullo, G., Nociti, V., Iorio, R., Patanella, A. K., Marti, A., Cammarota, G., Mirabella, M., Tonali, P. A., Batocchi, A. P., Increased expression of T-bet in circulating B cells from a patient with multiple sclerosis and celiac disease, <<HUMAN IMMUNOLOGY>>, 2008; 69 (12): 837-839. [doi:10.1016/j.humimm.2008.09.008] [http://hdl.handle.net/10807/19448]

Increased expression of T-bet in circulating B cells from a patient with multiple sclerosis and celiac disease

Frisullo, Giovanni;Nociti, Viviana;Iorio, Raffaele;Patanella, Agata Katia;Marti, Alessandro;Cammarota, Giovanni;Mirabella, Massimiliano;Batocchi, Anna Paola
2008

Abstract

Multiple sclerosis (MS) and celiac disease (CD) are considered to be T-cell-mediated autoimmune diseases. We describe a woman affected by a relapsing-remitting demyelinating disease of the central nervous system and occult CD (MS-CD), who showed during neurologic exacerbations a strong increased expression of T-bet, the key transcription factor for the development of Th1 cells, in circulating T, B cells and monocytes. Conversely, no difference of T-bet expression was observed in B cells from relapsing-remitting MS patients, either in relapse or in remission, and in controls. In the MS-CD patient, the interaction between MS- and CD-related inflammatory processes may result in an amplification of Th1 immune response
2008
Inglese
Frisullo, G., Nociti, V., Iorio, R., Patanella, A. K., Marti, A., Cammarota, G., Mirabella, M., Tonali, P. A., Batocchi, A. P., Increased expression of T-bet in circulating B cells from a patient with multiple sclerosis and celiac disease, <<HUMAN IMMUNOLOGY>>, 2008; 69 (12): 837-839. [doi:10.1016/j.humimm.2008.09.008] [http://hdl.handle.net/10807/19448]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/19448
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