Background: The aim of this study is to identify miRNAs able to predict the outcomes in breast cancer patients after neoadjuvant chemotherapy (NAC). Patients and methods: We retrospec-tively analyzed 24 patients receiving NAC and not reaching pathologic complete response (pCR). miRNAs were analyzed using an Illumina Next‐Generation‐Sequencing (NGS) system. Results: Event‐free survival (EFS) and overall survival (OS) were significantly higher in patients with up-regulation of let‐7a‐5p (EFS p = 0.006; OS p = 0.0001), mirR‐100‐5p (EFS s p = 0.01; OS p = 0.03), miR‐ 101‐3p (EFS p = 0.05; OS p = 0.01), and miR‐199a‐3p (EFS p = 0.02; OS p = 0.01) in post‐NAC samples, independently from breast cancer subtypes. At multivariate analysis, only let‐7a‐5p was significantly associated with EFS (p = 0.009) and OS (p = 0.0008). Conclusion: Up‐regulation of the above miRNAs could represent biomarkers in breast cancer.

Fuso, P., Di Salvatore, M., Santonocito, C., Guarino, D., Autilio, C., Mule, A., Arciuolo, D., Rinninella, A., Mignone, F., Ramundo, M., Di Stefano, B., Orlandi, A., Capoluongo, E., Nicolotti, N., Franceschini, G., Sanchez, A. M., Tortora, G., Scambia, G., Barone, C., Cassano, A., Let‐7a‐5p, mir‐100‐5p, mir‐101‐3p, and mir‐199a‐3p hyperexpression as potential predictive biomarkers in early breast cancer patients, <<JOURNAL OF PERSONALIZED MEDICINE>>, 2021; 11 (8): 1-17. [doi:10.3390/jpm11080816] [http://hdl.handle.net/10807/190389]

Let‐7a‐5p, mir‐100‐5p, mir‐101‐3p, and mir‐199a‐3p hyperexpression as potential predictive biomarkers in early breast cancer patients

Fuso, P.;Di Salvatore, M.;Santonocito, C.;Guarino, D.;Arciuolo, D.;Mignone, F.;Orlandi, A.;Capoluongo, E.;Nicolotti, N.;Franceschini, G.;Tortora, G.;Scambia, G.;Cassano, A.
2021

Abstract

Background: The aim of this study is to identify miRNAs able to predict the outcomes in breast cancer patients after neoadjuvant chemotherapy (NAC). Patients and methods: We retrospec-tively analyzed 24 patients receiving NAC and not reaching pathologic complete response (pCR). miRNAs were analyzed using an Illumina Next‐Generation‐Sequencing (NGS) system. Results: Event‐free survival (EFS) and overall survival (OS) were significantly higher in patients with up-regulation of let‐7a‐5p (EFS p = 0.006; OS p = 0.0001), mirR‐100‐5p (EFS s p = 0.01; OS p = 0.03), miR‐ 101‐3p (EFS p = 0.05; OS p = 0.01), and miR‐199a‐3p (EFS p = 0.02; OS p = 0.01) in post‐NAC samples, independently from breast cancer subtypes. At multivariate analysis, only let‐7a‐5p was significantly associated with EFS (p = 0.009) and OS (p = 0.0008). Conclusion: Up‐regulation of the above miRNAs could represent biomarkers in breast cancer.
Inglese
Fuso, P., Di Salvatore, M., Santonocito, C., Guarino, D., Autilio, C., Mule, A., Arciuolo, D., Rinninella, A., Mignone, F., Ramundo, M., Di Stefano, B., Orlandi, A., Capoluongo, E., Nicolotti, N., Franceschini, G., Sanchez, A. M., Tortora, G., Scambia, G., Barone, C., Cassano, A., Let‐7a‐5p, mir‐100‐5p, mir‐101‐3p, and mir‐199a‐3p hyperexpression as potential predictive biomarkers in early breast cancer patients, <<JOURNAL OF PERSONALIZED MEDICINE>>, 2021; 11 (8): 1-17. [doi:10.3390/jpm11080816] [http://hdl.handle.net/10807/190389]
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