The independent effects of smoking and alcohol in head and neck cancer are not clear, given the strong association between these risk factors. Their apparent synergistic effect reported in previous observational studies may also underestimate independent effects. Here we report multivariable Mendelian randomization performed in a two-sample approach using summary data on 6,034 oral/oropharyngeal cases and 6,585 controls from a recent genome-wide association study. Our results demonstrate strong evidence for an independent causal effect of smoking on oral/oropharyngeal cancer (IVW OR 2.6, 95% CI = 1.7, 3.9 per standard deviation increase in lifetime smoking behaviour) and an independent causal effect of alcohol consumption when controlling for smoking (IVW OR 2.1, 95% CI = 1.1, 3.8 per standard deviation increase in drinks consumed per week). This suggests the possibility that the causal effect of alcohol may have been underestimated. However, the extent to which alcohol is modified by smoking requires further investigation.

Gormley, M., Dudding, T., Sanderson, E., Martin, R. M., Thomas, S., Tyrrell, J., Ness, A. R., Brennan, P., Munafo, M., Pring, M., Boccia, S., Olshan, A. F., Diergaarde, B., Hung, R. J., Liu, G., Davey Smith, G., Richmond, R. C., A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer, <<NATURE COMMUNICATIONS>>, 2020; 11 (1): 1-10. [doi:10.1038/s41467-020-19822-6] [http://hdl.handle.net/10807/186806]

A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer

Boccia, Stefania;Liu, Guopeng;
2020

Abstract

The independent effects of smoking and alcohol in head and neck cancer are not clear, given the strong association between these risk factors. Their apparent synergistic effect reported in previous observational studies may also underestimate independent effects. Here we report multivariable Mendelian randomization performed in a two-sample approach using summary data on 6,034 oral/oropharyngeal cases and 6,585 controls from a recent genome-wide association study. Our results demonstrate strong evidence for an independent causal effect of smoking on oral/oropharyngeal cancer (IVW OR 2.6, 95% CI = 1.7, 3.9 per standard deviation increase in lifetime smoking behaviour) and an independent causal effect of alcohol consumption when controlling for smoking (IVW OR 2.1, 95% CI = 1.1, 3.8 per standard deviation increase in drinks consumed per week). This suggests the possibility that the causal effect of alcohol may have been underestimated. However, the extent to which alcohol is modified by smoking requires further investigation.
2020
Inglese
Gormley, M., Dudding, T., Sanderson, E., Martin, R. M., Thomas, S., Tyrrell, J., Ness, A. R., Brennan, P., Munafo, M., Pring, M., Boccia, S., Olshan, A. F., Diergaarde, B., Hung, R. J., Liu, G., Davey Smith, G., Richmond, R. C., A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer, <<NATURE COMMUNICATIONS>>, 2020; 11 (1): 1-10. [doi:10.1038/s41467-020-19822-6] [http://hdl.handle.net/10807/186806]
File in questo prodotto:
File Dimensione Formato  
Gormley NAtComm 2020.pdf

accesso aperto

Tipologia file ?: Versione Editoriale (PDF)
Licenza: Creative commons
Dimensione 876.61 kB
Formato Adobe PDF
876.61 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/186806
Citazioni
  • ???jsp.display-item.citation.pmc??? 29
  • Scopus 49
  • ???jsp.display-item.citation.isi??? 49
social impact