Children suffering from Acute Lymphoblastic Leukaemia (ALL) treated with asparaginase and corticosteroids are at risk of developing severe lipid abnormalities. The authors report the case of a 10-year-old male with extremely high plasma triglyceride concentrations (4,000 mg/dl) during the induction phase of ALL associated with mild pancreatitis. Hypertriglyceridemia was successfully managed with plasmapheresis with a decrease in triglyceride levels to 590 mg/dl. Apheresis appears to be safe and effective in reducing hypertriglyceridemia and preventing related complications.
Ridola, V., Buonuomo, P. S., Maurizi, P., Putzulu, R., Riccardi, R., Severe acute hypertriglyceridemia during acute lymphoblastic leukemia inductionsuccessfully treated with plasmapheresis., <<PEDIATRIC BLOOD & CANCER>>, 2008; (50(2)): 378-380. [doi:10.1002/pbc.20986] [http://hdl.handle.net/10807/18329]
Severe acute hypertriglyceridemia during acute lymphoblastic leukemia induction successfully treated with plasmapheresis.
Ridola, Vita;Buonuomo, Paola Sabrina;Maurizi, Palma;Putzulu, Rossana;Riccardi, Riccardo
2008
Abstract
Children suffering from Acute Lymphoblastic Leukaemia (ALL) treated with asparaginase and corticosteroids are at risk of developing severe lipid abnormalities. The authors report the case of a 10-year-old male with extremely high plasma triglyceride concentrations (4,000 mg/dl) during the induction phase of ALL associated with mild pancreatitis. Hypertriglyceridemia was successfully managed with plasmapheresis with a decrease in triglyceride levels to 590 mg/dl. Apheresis appears to be safe and effective in reducing hypertriglyceridemia and preventing related complications.
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