Epileptic seizures are a common clinical problem in children with brain tumors. The conventional antiepileptic drugs (AEDs) permit a good seizure control in most of these children. An emerging problem is the possible interactions between AEDs and chemotherapeutic drugs, because many of these drugs are metabolized by the cytochrome P450. The aim of this article is to propose a novel therapeutic approach for new-onset epilepsy in children with brain tumors. Among the new AEDs not metabolized by the P450 system, levetiracetam seems to be a promising AED owing to its pharmacokinetic features, efficacy, and safety

Ruggiero, A., Rizzo, D., Mastrangelo, S., Battaglia, D. I., Attina', G., Riccardi, R., Interactions between antiepileptic and chemoterapeutic drugs in children with brain tumors: is it time to change treatment?, <<PEDIATRIC BLOOD & CANCER>>, 2010; 54 (2): 193-198 [http://hdl.handle.net/10807/18278]

Interactions between antiepileptic and chemoterapeutic drugs in children with brain tumors: is it time to change treatment?

Ruggiero, Antonio;Rizzo, Daniela;Mastrangelo, Stefano;Battaglia, Domenica Immacolata;Attina', Giorgio;Riccardi, Riccardo
2010

Abstract

Epileptic seizures are a common clinical problem in children with brain tumors. The conventional antiepileptic drugs (AEDs) permit a good seizure control in most of these children. An emerging problem is the possible interactions between AEDs and chemotherapeutic drugs, because many of these drugs are metabolized by the cytochrome P450. The aim of this article is to propose a novel therapeutic approach for new-onset epilepsy in children with brain tumors. Among the new AEDs not metabolized by the P450 system, levetiracetam seems to be a promising AED owing to its pharmacokinetic features, efficacy, and safety
Inglese
Ruggiero, A., Rizzo, D., Mastrangelo, S., Battaglia, D. I., Attina', G., Riccardi, R., Interactions between antiepileptic and chemoterapeutic drugs in children with brain tumors: is it time to change treatment?, <<PEDIATRIC BLOOD & CANCER>>, 2010; 54 (2): 193-198 [http://hdl.handle.net/10807/18278]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/18278
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