Individuals with Down syndrome (DS) have an increased incidence of leukaemia. They have elevated relapse rates and therapy‐related mortality (TRM).1-4 Approximately 30%–50% of adult patients affected by acute lymphoblastic leukaemia (ALL) in haematological complete remission (CR) exhibit minimal residual disease (MRD) and this is the strongest predictor of relapse. We aimed to describe the clinical outcome of three adult DS patients treated with blinatumomab5, 6 as rescue for refractory/relapsed ALL (Table 1) . All patients had a diagnosis of Ph negative B‐cell ALL without extramedullary involvement at diagnosis or additional cytogenetic abnormalities.

Sica, S., Blinatumomab as a successful and safe therapyin Down syndrome patients with relapsed / refractory b-precursor acute lymphoblastic leukemia: Case report and literature review, <<PEDIATRIC BLOOD & CANCER>>, 2021; (12): 1-4 [http://hdl.handle.net/10807/179251]

Blinatumomab as a successful and safe therapyin Down syndrome patients with relapsed / refractory b-precursor acute lymphoblastic leukemia: Case report and literature review

Sica, Simona
Ultimo
Membro del Collaboration Group
2021

Abstract

Individuals with Down syndrome (DS) have an increased incidence of leukaemia. They have elevated relapse rates and therapy‐related mortality (TRM).1-4 Approximately 30%–50% of adult patients affected by acute lymphoblastic leukaemia (ALL) in haematological complete remission (CR) exhibit minimal residual disease (MRD) and this is the strongest predictor of relapse. We aimed to describe the clinical outcome of three adult DS patients treated with blinatumomab5, 6 as rescue for refractory/relapsed ALL (Table 1) . All patients had a diagnosis of Ph negative B‐cell ALL without extramedullary involvement at diagnosis or additional cytogenetic abnormalities.
2021
Inglese
Sica, S., Blinatumomab as a successful and safe therapyin Down syndrome patients with relapsed / refractory b-precursor acute lymphoblastic leukemia: Case report and literature review, <<PEDIATRIC BLOOD & CANCER>>, 2021; (12): 1-4 [http://hdl.handle.net/10807/179251]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/179251
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