Background: Hyalinizing trabecular tumors (HTTs) are rare, essentially benign, follicular cell–derived thyroid neoplasms characterized by a trabecular growth pattern and nuclear pseudoinclusions. Their cytological findings are misleading, because these tumors are often misinterpreted on fine needle aspirate cytology as malignant lesions, such as papillary thyroid cancer and/or medullary thyroid cancer, leading to unnecessary total thyroidectomy. The aim of this study was to analyze the cytomorphological features and application of ancillary techniques in a series of HTTs. Methods: Of 26 histological cases of HTT collected from September 2001 to December 2018, 18 cases had concomitant cytopathology. Cytological cases were processed with liquid-based cytology (LBC). Immunocytochemistry for HBME-1 and galectine-3 as well as molecular testing for BRAFV600E mutation were performed on both LBC and histological specimens. Results: The 18 lesions with fine needle aspirate cytology ranged in size from 5 to 45 mm. Cytological diagnoses included: 1 benign lesion favoring goiter (5.5%), 4 atypia of undetermined significance (22.2%), 6 follicular neoplasms (33.3%), 5 suspicious for malignancy favoring papillary thyroid cancer (28%), and 2 malignant (11%). Hence, 89% HTT had a negative concordant immunopanel, and they were 100% wild-type BRAFV600E. Conclusion: The majority of our HTTs (83.3%) were diagnosed in the indeterminate Bethesda categories, suggesting that their cytomorphological features pose issues for reaching a conclusive cytological diagnosis. The ancillary test results in our series support the fact that HTT is a benign neoplasm.

Dell'aquila, M., Gravina, C., Cocomazzi, A., Capodimonti, S., Musarra, T., Sfregola, S., Fiorentino, V., Revelli, L., Martini, M., Fadda, G., Pantanowitz, L., Larocca, L. M., Rossi, E., A large series of hyalinizing trabecular tumors: Cytomorphology and ancillary techniques on fine needle aspiration, <<CANCER CYTOPATHOLOGY>>, 2019; 127 (6): 390-398. [doi:10.1002/cncy.22139] [http://hdl.handle.net/10807/178339]

A large series of hyalinizing trabecular tumors: Cytomorphology and ancillary techniques on fine needle aspiration

Dell'Aquila, M.;Cocomazzi, A.;Capodimonti, S.;Sfregola, S.;Revelli, L.;Martini, M.;Larocca, L. M.;Rossi, E.
Ultimo
2019

Abstract

Background: Hyalinizing trabecular tumors (HTTs) are rare, essentially benign, follicular cell–derived thyroid neoplasms characterized by a trabecular growth pattern and nuclear pseudoinclusions. Their cytological findings are misleading, because these tumors are often misinterpreted on fine needle aspirate cytology as malignant lesions, such as papillary thyroid cancer and/or medullary thyroid cancer, leading to unnecessary total thyroidectomy. The aim of this study was to analyze the cytomorphological features and application of ancillary techniques in a series of HTTs. Methods: Of 26 histological cases of HTT collected from September 2001 to December 2018, 18 cases had concomitant cytopathology. Cytological cases were processed with liquid-based cytology (LBC). Immunocytochemistry for HBME-1 and galectine-3 as well as molecular testing for BRAFV600E mutation were performed on both LBC and histological specimens. Results: The 18 lesions with fine needle aspirate cytology ranged in size from 5 to 45 mm. Cytological diagnoses included: 1 benign lesion favoring goiter (5.5%), 4 atypia of undetermined significance (22.2%), 6 follicular neoplasms (33.3%), 5 suspicious for malignancy favoring papillary thyroid cancer (28%), and 2 malignant (11%). Hence, 89% HTT had a negative concordant immunopanel, and they were 100% wild-type BRAFV600E. Conclusion: The majority of our HTTs (83.3%) were diagnosed in the indeterminate Bethesda categories, suggesting that their cytomorphological features pose issues for reaching a conclusive cytological diagnosis. The ancillary test results in our series support the fact that HTT is a benign neoplasm.
Inglese
Dell'aquila, M., Gravina, C., Cocomazzi, A., Capodimonti, S., Musarra, T., Sfregola, S., Fiorentino, V., Revelli, L., Martini, M., Fadda, G., Pantanowitz, L., Larocca, L. M., Rossi, E., A large series of hyalinizing trabecular tumors: Cytomorphology and ancillary techniques on fine needle aspiration, <<CANCER CYTOPATHOLOGY>>, 2019; 127 (6): 390-398. [doi:10.1002/cncy.22139] [http://hdl.handle.net/10807/178339]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/178339
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 4
social impact