There are several reports dealing with the hepatic effect of FK 506,1–4 some of which are beneficial while others are adverse. Because the liver is a major target organ that is often the site of drug toxicity, studies directed at determining whether FK 506 affects specific hepatic function and/or its histologic appearance are important. Therefore, the present study was undertaken to examine bromosulphthalein (BSP) elimination kinetics in rats as a sensitive index of hepatic excretory function under the influence of FK 506 in the rat.

Farghali, H., Sakr, M., Gasbarrini, A., Venkataramanan, R., Gavaler, J., Starzl, T., Van Thiel, D., Effect of FK 506 chronic administration on bromosulphthalein hepatic excretion in rats, <<TRANSPLANTATION PROCEEDINGS>>, 1991; 23 (6): 2802-2804 [http://hdl.handle.net/10807/17730]

Effect of FK 506 chronic administration on bromosulphthalein hepatic excretion in rats

Gasbarrini, Antonio;
1991

Abstract

There are several reports dealing with the hepatic effect of FK 506,1–4 some of which are beneficial while others are adverse. Because the liver is a major target organ that is often the site of drug toxicity, studies directed at determining whether FK 506 affects specific hepatic function and/or its histologic appearance are important. Therefore, the present study was undertaken to examine bromosulphthalein (BSP) elimination kinetics in rats as a sensitive index of hepatic excretory function under the influence of FK 506 in the rat.
1991
AREA06 - SCIENZE MEDICHE
Pubblicazione su rivista con Impact Factor
Inglese
Articolo in rivista
Inglese
Administration, Oral
Animals
Dose-Response Relationship, Drug
Kinetics
Liver
Male
Rats
Rats, Inbred Strains
Sulfobromophthalein
Tacrolimus
Time Factors
Settore MED/09 - MEDICINA INTERNA
23
6
1991
2802
2804
3
info:eu-repo/semantics/article
Farghali, H., Sakr, M., Gasbarrini, A., Venkataramanan, R., Gavaler, J., Starzl, T., Van Thiel, D., Effect of FK 506 chronic administration on bromosulphthalein hepatic excretion in rats, <<TRANSPLANTATION PROCEEDINGS>>, 1991; 23 (6): 2802-2804 [http://hdl.handle.net/10807/17730]
none
262
Farghali, H; Sakr, M; Gasbarrini, Antonio; Venkataramanan, R; Gavaler, J; Starzl, Te; Van Thiel, Dh
7
art_per_29
03. Contributo in rivista::Articolo in rivista, Nota a sentenza
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/17730
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact