Myasthenia gravis (MG) and paraneoplastic cerebellar degeneration (PCD) are immune-mediated syndromes that can represent paraneoplastic disorders. We report a patient with history of ovarian carcinoma that presented with ptosis, diplopia and gait ataxia. Neurophysiological examination and laboratory tests revealed the presence of MG and PCD. An integrated FDG-PET/contrast-enhanced CT scan showed tumor recurrence. This is to the best of our knowledge the first association of MG and PCD with recurring ovarian carcinoma.
Caliandro, P., Luigetti, M., Ricci, E., Mirabella, M., Tonali, P. A., Padua, L., Cerebellar degeneration and ocular myasthenia gravis in a patient with recurring ovarian carcinoma., <<NEUROLOGICAL SCIENCES>>, 2010; (Febbraio): 79-81. [doi:doi: 10.1007/s10072-009-0154-3] [http://hdl.handle.net/10807/17394]
Cerebellar degeneration and ocular myasthenia gravis in a patient with recurring ovarian carcinoma.
Caliandro, Pietro;Luigetti, Marco;Ricci, Enzo;Mirabella, Massimiliano;Tonali, Pietro Attilio;Padua, Luca
2010
Abstract
Myasthenia gravis (MG) and paraneoplastic cerebellar degeneration (PCD) are immune-mediated syndromes that can represent paraneoplastic disorders. We report a patient with history of ovarian carcinoma that presented with ptosis, diplopia and gait ataxia. Neurophysiological examination and laboratory tests revealed the presence of MG and PCD. An integrated FDG-PET/contrast-enhanced CT scan showed tumor recurrence. This is to the best of our knowledge the first association of MG and PCD with recurring ovarian carcinoma.
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