BACKGROUND AND OBJECTIVE: To compare morphologic and functional status at age 4 years for patients treated in one eye with laser photocoagulation and the other eye with intravitreal bevacizumab (IVB) injection for Type 1 retinopathy of prematurity (ROP). PATIENTS AND METHODS: In this single-center, randomized, controlled trial, best-corrected visual acuity (BCVA) in logMAR was obtained along with spherical equivalent refraction (SER), fluorescein angiography (FA), optical coherent tomography (OCT), and OCT angiography (OCTA). RESULTS: Eighteen babies (36 eyes) were selected for this study. BCVA and SER were similar in the two groups, but six patients had anisometropia of 4 diopters or more. IVB-treated eyes tended to have thinner foveal thickness than laser-treated eyes (mean difference: –5.33 pixels; 95% confidence interval, –9.62 to –1.05). CONCLUSION: Although the differences found here are minimal between the IVB-treated and laser-treated groups, further long-term evaluation of not only FA, but also OCT and OCTA, are needed in larger studies.

Lepore, D., Ji, M. H., Quinn, G. E., Amorelli, G. M., Orazi, L., Ricci, D., Mercuri, E. M., Functional and morphologic findings at four years after intravitreal bevacizumab or laser for type 1 ROP, <<OPHTHALMIC SURGERY, LASERS & IMAGING>>, 2020; 51 (3): 180-186. [doi:10.3928/23258160-20200228-07] [http://hdl.handle.net/10807/172070]

Functional and morphologic findings at four years after intravitreal bevacizumab or laser for type 1 ROP

Lepore, Domenico
Primo
Writing – Original Draft Preparation
;
Amorelli, Giulia Maria
Writing – Review & Editing
;
Ricci, Daniela
Writing – Review & Editing
;
Mercuri, Eugenio Maria
Supervision
2020

Abstract

BACKGROUND AND OBJECTIVE: To compare morphologic and functional status at age 4 years for patients treated in one eye with laser photocoagulation and the other eye with intravitreal bevacizumab (IVB) injection for Type 1 retinopathy of prematurity (ROP). PATIENTS AND METHODS: In this single-center, randomized, controlled trial, best-corrected visual acuity (BCVA) in logMAR was obtained along with spherical equivalent refraction (SER), fluorescein angiography (FA), optical coherent tomography (OCT), and OCT angiography (OCTA). RESULTS: Eighteen babies (36 eyes) were selected for this study. BCVA and SER were similar in the two groups, but six patients had anisometropia of 4 diopters or more. IVB-treated eyes tended to have thinner foveal thickness than laser-treated eyes (mean difference: –5.33 pixels; 95% confidence interval, –9.62 to –1.05). CONCLUSION: Although the differences found here are minimal between the IVB-treated and laser-treated groups, further long-term evaluation of not only FA, but also OCT and OCTA, are needed in larger studies.
2020
Inglese
Lepore, D., Ji, M. H., Quinn, G. E., Amorelli, G. M., Orazi, L., Ricci, D., Mercuri, E. M., Functional and morphologic findings at four years after intravitreal bevacizumab or laser for type 1 ROP, <<OPHTHALMIC SURGERY, LASERS & IMAGING>>, 2020; 51 (3): 180-186. [doi:10.3928/23258160-20200228-07] [http://hdl.handle.net/10807/172070]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/172070
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