Abstract A low count of CD4+ and CD8+ lymphocytes is a hallmark laboratory finding in the coronavirus disease 2019 (COVID-19). Using flow cytometry, we observed significantly higher CD95 (Fas) and PD-1 expression on both CD4+ T and CD8+ T cells in 42 COVID-19 patients when compared to controls. Higher CD95 expression in CD4+ cells correlated with lower CD4+ counts. A higher expression of CD95 in CD4+ and CD8+ lymphocytes correlated with a lower percentage of naive events. Our results might suggest a shift to antigen-activated T cells, expressing molecules increasing their propensity to apoptosis and exhaustion during COVID-19 infection. Keywords: CD95 (Fas); COVID-19; PD-1; apoptosis; exhaustio
Sica, S., Increased CD95 (Fas) and PD-1 expression in peripheral blood T lymphocytes in COVID -19 patients, <<BRITISH JOURNAL OF HAEMATOLOGY>>, 2020; (191): 207-211 [http://hdl.handle.net/10807/169272]
Increased CD95 (Fas) and PD-1 expression in peripheral blood T lymphocytes in COVID -19 patients
Sica, Simona
Secondo
Membro del Collaboration Group
2019
Abstract
Abstract A low count of CD4+ and CD8+ lymphocytes is a hallmark laboratory finding in the coronavirus disease 2019 (COVID-19). Using flow cytometry, we observed significantly higher CD95 (Fas) and PD-1 expression on both CD4+ T and CD8+ T cells in 42 COVID-19 patients when compared to controls. Higher CD95 expression in CD4+ cells correlated with lower CD4+ counts. A higher expression of CD95 in CD4+ and CD8+ lymphocytes correlated with a lower percentage of naive events. Our results might suggest a shift to antigen-activated T cells, expressing molecules increasing their propensity to apoptosis and exhaustion during COVID-19 infection. Keywords: CD95 (Fas); COVID-19; PD-1; apoptosis; exhaustio
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