MIst test and a test base on the inhalation of a 10% solution of citric acid were performed in 10 symptom-free asthmatic subjects in order to compare their effectiveness as bronchial challenges. the mean percentage decrease of SGaw was 30.4 + 16.4 after citric acid and 52.4 +14.9 after artificial fog (mist test). Mist test showed a hyperreactive condition in all tested subjects. Instead, citric acid induced a significant response in only 4 subjects though it always gave rise to adverse effects (cough, lachrymation, local burning, and vomit). We conclude that citric acid is more discomfortable and less effective than mist test and that, therefore, lacks the basic features of a good bronchial challenge test.
Dardes, N., Rosati, G., Mormile, F., Inhaled citric acid as bronchial challenge: A comparison with the ultrasonically nebulized distilled water, <<ACTA MEDICA ROMANA>>, 1981; 19 (4): 405-411 [http://hdl.handle.net/10807/164523]
Inhaled citric acid as bronchial challenge: A comparison with the ultrasonically nebulized distilled water
Mormile, Flaminio
1981
Abstract
MIst test and a test base on the inhalation of a 10% solution of citric acid were performed in 10 symptom-free asthmatic subjects in order to compare their effectiveness as bronchial challenges. the mean percentage decrease of SGaw was 30.4 + 16.4 after citric acid and 52.4 +14.9 after artificial fog (mist test). Mist test showed a hyperreactive condition in all tested subjects. Instead, citric acid induced a significant response in only 4 subjects though it always gave rise to adverse effects (cough, lachrymation, local burning, and vomit). We conclude that citric acid is more discomfortable and less effective than mist test and that, therefore, lacks the basic features of a good bronchial challenge test.
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