Fusarium mycotoxins are secondary metabolites produced by Fusarium spp. in cereals. Among them, deoxynivalenol (DON) and zearalenone (ZEN) are widespread worldwide contaminants of cereal commodities and are ranked as the most important chronic dietary risk factors. Their conjugates, known as masked mycotoxins, have been described but are still not accounted for in risk assessment studies. This study demonstrates for the first time that DON and ZEN are effectively deconjugated by the human colonic microbiota, releasing their toxic aglycones and generating yet unidentified catabolites. For this reason, masked mycotoxins should be considered when evaluating population exposure. © 2013 American Chemical Society.

Dall'Erta, A., Cirlini, M., Dall'Asta, M., Del Rio, D., Galaverna, G., Dall'Asta, C., Masked mycotoxins are efficiently hydrolyzed by human colonic microbiota releasing their aglycones, <<CHEMICAL RESEARCH IN TOXICOLOGY>>, 2013; 26 (3): 305-312. [doi:10.1021/tx300438c] [http://hdl.handle.net/10807/163877]

Masked mycotoxins are efficiently hydrolyzed by human colonic microbiota releasing their aglycones

Dall'Asta, Margherita;
2013

Abstract

Fusarium mycotoxins are secondary metabolites produced by Fusarium spp. in cereals. Among them, deoxynivalenol (DON) and zearalenone (ZEN) are widespread worldwide contaminants of cereal commodities and are ranked as the most important chronic dietary risk factors. Their conjugates, known as masked mycotoxins, have been described but are still not accounted for in risk assessment studies. This study demonstrates for the first time that DON and ZEN are effectively deconjugated by the human colonic microbiota, releasing their toxic aglycones and generating yet unidentified catabolites. For this reason, masked mycotoxins should be considered when evaluating population exposure. © 2013 American Chemical Society.
2013
Inglese
Dall'Erta, A., Cirlini, M., Dall'Asta, M., Del Rio, D., Galaverna, G., Dall'Asta, C., Masked mycotoxins are efficiently hydrolyzed by human colonic microbiota releasing their aglycones, <<CHEMICAL RESEARCH IN TOXICOLOGY>>, 2013; 26 (3): 305-312. [doi:10.1021/tx300438c] [http://hdl.handle.net/10807/163877]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/163877
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