The January issue of Trends in Immunology contained an interesting article by Kaplanski et al., in which the authors observed that interleukin-6 (IL-6) acts as a switch, regulating the transition from neutrophil to monocyte involvement during the inflammatory response [1]. In this model, activated polymorphonuclear (PMN) cells release soluble interleukin-6 receptor a (sIL-6Ra), which, upon binding of locally produced IL-6, combines with glycoprotein 130 (gp130) on endothelial cells, enabling them to switch from IL-8 (neutrophil-recruiting) to monocyte chemotactic protein-1 (monocyte-recruiting) secretion
Bartoccioni, E., Scuderi, F., Marino, M., Provenzano, C., Kaplanski, G., Marin, V., Farnarier, C., IL-6, monocyte infiltration and parenchymal cells, <<TRENDS IN IMMUNOLOGY>>, 2003; 24 (6): 298-299. [doi:10.1016/S1471-4906(03)00112-1] [http://hdl.handle.net/10807/163618]
IL-6, monocyte infiltration and parenchymal cells
Bartoccioni, E.
Primo
;Scuderi, F.Secondo
;Marino, M.Penultimo
;Provenzano, C.Ultimo
;
2003
Abstract
The January issue of Trends in Immunology contained an interesting article by Kaplanski et al., in which the authors observed that interleukin-6 (IL-6) acts as a switch, regulating the transition from neutrophil to monocyte involvement during the inflammatory response [1]. In this model, activated polymorphonuclear (PMN) cells release soluble interleukin-6 receptor a (sIL-6Ra), which, upon binding of locally produced IL-6, combines with glycoprotein 130 (gp130) on endothelial cells, enabling them to switch from IL-8 (neutrophil-recruiting) to monocyte chemotactic protein-1 (monocyte-recruiting) secretionI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.