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EnglishWe studied the expression of MHC-I and MHC-II molecules and ICAM-1 in cultured human myoblasts in response to IL-1β, IL-4, IL-6, IFN-γ and LPS. IFN-γ, LPS and IL-4 greatly increase MHC-I molecule expression. MHC-II molecule expression is induced only by IFN-γ. Membrane ICAM-1 and mRNA expression are absent under basal conditions, but can be induced by IFN-γ, IL-1β, IL-4, LPS and IL-6 with different efficiencies and time-courses. Soluble ICAM-1 secretion can be induced to a different extent by all cytokines. Our study shows that the expression of adhesion-related molecules in muscle is finely regulated by these cytokines. © 2001 Elsevier Science B.V.
Marino, M., Scuderi, F., Mazzarelli, P., Mannella, F., Provenzano, C., Bartoccioni, E., Constitutive and cytokine-induced expression of MHC and intercellular adhesion molecule-1 (ICAM-1) on human myoblasts, <<JOURNAL OF NEUROIMMUNOLOGY>>, 2001; 116 (1): 94-101. [doi:10.1016/S0165-5728(01)00287-9] [http://hdl.handle.net/10807/163610]
| Autori: | |
| Titolo: | Constitutive and cytokine-induced expression of MHC and intercellular adhesion molecule-1 (ICAM-1) on human myoblasts |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/S0165-5728(01)00287-9 |
| Data di pubblicazione: | 2001 |
| Abstract: | We studied the expression of MHC-I and MHC-II molecules and ICAM-1 in cultured human myoblasts in response to IL-1β, IL-4, IL-6, IFN-γ and LPS. IFN-γ, LPS and IL-4 greatly increase MHC-I molecule expression. MHC-II molecule expression is induced only by IFN-γ. Membrane ICAM-1 and mRNA expression are absent under basal conditions, but can be induced by IFN-γ, IL-1β, IL-4, LPS and IL-6 with different efficiencies and time-courses. Soluble ICAM-1 secretion can be induced to a different extent by all cytokines. Our study shows that the expression of adhesion-related molecules in muscle is finely regulated by these cytokines. © 2001 Elsevier Science B.V. |
| Lingua: | Inglese |
| Rivista: | |
| Citazione: | Marino, M., Scuderi, F., Mazzarelli, P., Mannella, F., Provenzano, C., Bartoccioni, E., Constitutive and cytokine-induced expression of MHC and intercellular adhesion molecule-1 (ICAM-1) on human myoblasts, <<JOURNAL OF NEUROIMMUNOLOGY>>, 2001; 116 (1): 94-101. [doi:10.1016/S0165-5728(01)00287-9] [http://hdl.handle.net/10807/163610] |
| Appare nelle tipologie: | Articolo in rivista, Nota a sentenza |
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