We have previously shown that interleukin (IL)-1β and other inflammatory cytokines are able to induce the expression of membrane and soluble intercellular adhesion molecule (ICAM)-1 on human myoblasts. In this paper we found that IL-10 and transforming growth factor (TGF)-β1 are able to prevent IL-1β-induced membrane and soluble ICAM-1 protein expression on human myoblasts, with different time courses. The effect of both cytokines is associated to a reduction in ICAM-1 mRNA. Our findings suggest that IL-10 and TGF-β1 are able to influence the inflammatory process in muscle tissue at least in part by means of control of membrane and soluble ICAM-1. © 2002 Elsevier Science B.V. All rights reserved.
Marino, M., Scuderi, F., Mannella, F., Bartoccioni, E., TGF-β1 and IL-10 modulate IL-1β-induced membrane and soluble ICAM-1 in human myoblasts, <<JOURNAL OF NEUROIMMUNOLOGY>>, 2003; 134 (1-2): 151-157. [doi:10.1016/S0165-5728(02)00399-5] [http://hdl.handle.net/10807/163579]
TGF-β1 and IL-10 modulate IL-1β-induced membrane and soluble ICAM-1 in human myoblasts
Marino, MariapaolaPrimo
;Scuderi, FlaviaSecondo
;Bartoccioni, Emanuela
Ultimo
2003
Abstract
We have previously shown that interleukin (IL)-1β and other inflammatory cytokines are able to induce the expression of membrane and soluble intercellular adhesion molecule (ICAM)-1 on human myoblasts. In this paper we found that IL-10 and transforming growth factor (TGF)-β1 are able to prevent IL-1β-induced membrane and soluble ICAM-1 protein expression on human myoblasts, with different time courses. The effect of both cytokines is associated to a reduction in ICAM-1 mRNA. Our findings suggest that IL-10 and TGF-β1 are able to influence the inflammatory process in muscle tissue at least in part by means of control of membrane and soluble ICAM-1. © 2002 Elsevier Science B.V. All rights reserved.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
