Veno-occlusive disease (VOD) of the liver is a severe complication of high-dose chemotherapy and allogeneic or autologous stem cell transplantation with potential fatal outcome. We report a case of severe VOD in a patient with a high-grade B-cell lymphoma. Liver-venule occlusion was confirmed by liver biopsy. Supportive care, fibrinolytic treatment with recombinant tissue plasminogen activator and defibrotide maintenance therapy led to complete resolution of VOD demonstrated at liver biopsy and with a follow-up of 44 months after autologous peripheral blood stem cell transplantation. The literature on VOD has been reviewed.

Palladino, M., Miele, L., Pompili, M., Forgione, A., Vellone, V. G., Vecchio, F. M., Chiusolo, P., Laurenti, L., Gasbarrini, G. B., Sica, S., Grieco, A., Severe veno-occlusive disease after autologous peripheral blood stem cell transplantation for high-grade non-Hodgkin lymphoma: report of a successfully managed case and a literature review of veno-occlusive disease., <<CLINICAL TRANSPLANTATION>>, 2008; (Novembre): 837-841 [http://hdl.handle.net/10807/16050]

Severe veno-occlusive disease after autologous peripheral blood stem cell transplantation for high-grade non-Hodgkin lymphoma: report of a successfully managed case and a literature review of veno-occlusive disease.

Palladino, Michele;Miele, Luca;Pompili, Maurizio;Forgione, Alessandra;Vellone, Valerio Gaetano;Vecchio, Fabio Maria;Chiusolo, Patrizia;Laurenti, Luca;Gasbarrini, Giovanni Battista;Sica, Simona;Grieco, Antonio
2008

Abstract

Veno-occlusive disease (VOD) of the liver is a severe complication of high-dose chemotherapy and allogeneic or autologous stem cell transplantation with potential fatal outcome. We report a case of severe VOD in a patient with a high-grade B-cell lymphoma. Liver-venule occlusion was confirmed by liver biopsy. Supportive care, fibrinolytic treatment with recombinant tissue plasminogen activator and defibrotide maintenance therapy led to complete resolution of VOD demonstrated at liver biopsy and with a follow-up of 44 months after autologous peripheral blood stem cell transplantation. The literature on VOD has been reviewed.
Inglese
Palladino, M., Miele, L., Pompili, M., Forgione, A., Vellone, V. G., Vecchio, F. M., Chiusolo, P., Laurenti, L., Gasbarrini, G. B., Sica, S., Grieco, A., Severe veno-occlusive disease after autologous peripheral blood stem cell transplantation for high-grade non-Hodgkin lymphoma: report of a successfully managed case and a literature review of veno-occlusive disease., <>, 2008; (Novembre): 837-841 [http://hdl.handle.net/10807/16050]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/16050
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