We analyzed the prognostic impact of levels of free light chains (FLC) in 106 patients with DLBCL, selecting 61 patients with a monoclonal (M) protein in serum, and 45 patients without a M protein as an IPI-matched control group. Patients with a M protein had higher levels of FLC, but these were not of prognostic significance in this group. The presence of a M protein nullified associations of κ-FLC with several laboratory parameters indicating immune system activation observed in patients without a M protein. Patients without M protein and κ-FLC >50 mg/L had a significant inferior event-free survival (p =.004). The presence of M protein of an IgM type at diagnosis was a negative outcome predictor (p =.008), while a non-IgM M protein did not significantly impact on prognosis. In conclusion, the prognostic performance of the FLC assay is altered by the presence of a M protein.

Maiolo, E., Alma, E., Napodano, C., Gulli, F., Bellesi, S., Cuccaro, A., Pocino, K., D'Alo', F., Iachini, M., Martini, M., Larocca, L. M., De Stefano, V., Basile, U., Hohaus, S., The prognostic impact of monoclonal immune globulin and free light chain secretion in diffuse large B cell lymphoma (DLBCL), <<LEUKEMIA & LYMPHOMA>>, 2020; 61 (5): 1133-1139-1139. [doi:10.1080/10428194.2019.1706731] [http://hdl.handle.net/10807/152275]

The prognostic impact of monoclonal immune globulin and free light chain secretion in diffuse large B cell lymphoma (DLBCL)

Maiolo, E.;Alma, E.;Napodano, C.;Bellesi, S.;Cuccaro, A.;Pocino, K.;D'Alo', F.;Iachini, M.;Martini, M.;Larocca, L. M.;De Stefano, V.;Basile, U.;Hohaus, S.
2019

Abstract

We analyzed the prognostic impact of levels of free light chains (FLC) in 106 patients with DLBCL, selecting 61 patients with a monoclonal (M) protein in serum, and 45 patients without a M protein as an IPI-matched control group. Patients with a M protein had higher levels of FLC, but these were not of prognostic significance in this group. The presence of a M protein nullified associations of κ-FLC with several laboratory parameters indicating immune system activation observed in patients without a M protein. Patients without M protein and κ-FLC >50 mg/L had a significant inferior event-free survival (p =.004). The presence of M protein of an IgM type at diagnosis was a negative outcome predictor (p =.008), while a non-IgM M protein did not significantly impact on prognosis. In conclusion, the prognostic performance of the FLC assay is altered by the presence of a M protein.
2019
Inglese
Maiolo, E., Alma, E., Napodano, C., Gulli, F., Bellesi, S., Cuccaro, A., Pocino, K., D'Alo', F., Iachini, M., Martini, M., Larocca, L. M., De Stefano, V., Basile, U., Hohaus, S., The prognostic impact of monoclonal immune globulin and free light chain secretion in diffuse large B cell lymphoma (DLBCL), <<LEUKEMIA & LYMPHOMA>>, 2020; 61 (5): 1133-1139-1139. [doi:10.1080/10428194.2019.1706731] [http://hdl.handle.net/10807/152275]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/152275
Citazioni
  • ???jsp.display-item.citation.pmc??? 3
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 7
social impact