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EnglishBackground: Respiratory alemtuzumab-related adverse events are clinically heterogeneous and include respiratory infections, infusion-related dyspnea, hypoxia and secondary autoimmune disorders. Case report: Here we report three cases of drug-induced lung disease following treatment with alemtuzumab in multiple sclerosis patients. First case was diagnosed as a non-specified intestitial pneumonitis associated with organizing pneumonia with subacute onset, second case was an acute respiratory distress syndrome with onset during second cycle, third case was a diffuse acute alveolar hemorrhage during first cycle infusion. All patients developed acute respiratory failure, reversible after steroid therapy. Conclusions: Clinicians should be aware to early recognize acute and subacute respiratory adverse events for a promptly management. In these patients re-treatment is challenging.
Bianco, A., Mari, P. -., Larici, A. R., Lucchini, M., Nociti, V., Losavio, F. A., De Fino, C., Cicchetti, G., Coraci, D., Richeldi, L., Mirabella, M., Alemtuzumab-induced lung injury in multiple sclerosis: Learning from adversity in three patients, <<MULTIPLE SCLEROSIS AND RELATED DISORDERS>>, 2020; 37 (37): 101450-101453. [doi:10.1016/j.msard.2019.101450] [http://hdl.handle.net/10807/151231]
| Autori: | ||
| Titolo: | Alemtuzumab-induced lung injury in multiple sclerosis: Learning from adversity in three patients | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.msard.2019.101450 | |
| Data di pubblicazione: | 2020 | |
| Abstract: | Background: Respiratory alemtuzumab-related adverse events are clinically heterogeneous and include respiratory infections, infusion-related dyspnea, hypoxia and secondary autoimmune disorders. Case report: Here we report three cases of drug-induced lung disease following treatment with alemtuzumab in multiple sclerosis patients. First case was diagnosed as a non-specified intestitial pneumonitis associated with organizing pneumonia with subacute onset, second case was an acute respiratory distress syndrome with onset during second cycle, third case was a diffuse acute alveolar hemorrhage during first cycle infusion. All patients developed acute respiratory failure, reversible after steroid therapy. Conclusions: Clinicians should be aware to early recognize acute and subacute respiratory adverse events for a promptly management. In these patients re-treatment is challenging. | |
| Lingua: | Inglese | |
| Rivista: | ||
| Citazione: | Bianco, A., Mari, P. -., Larici, A. R., Lucchini, M., Nociti, V., Losavio, F. A., De Fino, C., Cicchetti, G., Coraci, D., Richeldi, L., Mirabella, M., Alemtuzumab-induced lung injury in multiple sclerosis: Learning from adversity in three patients, <<MULTIPLE SCLEROSIS AND RELATED DISORDERS>>, 2020; 37 (37): 101450-101453. [doi:10.1016/j.msard.2019.101450] [http://hdl.handle.net/10807/151231] | |
| Appare nelle tipologie: | Editoriale in rivista |
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