Aim: The aim of this study was to detect clinical factors predictive of loss of visual acuity after treatment in order to develop a predictive model to help identify patients at risk of visual loss. Patients and Methods: This was a retrospective review of patients who underwent interventional radiotherapy (brachytherapy) with 106Ru plaque for primary uveal melanoma. A predictive nomogram for visual acuity loss at 3 years from treatment was developed. Results: A total of 152 patients were selected for the study. The actuarial probability of conservation of 20/40 vision or better was 0.74 at 1 year, 0.59 at 3 years, and 0.54 at 5 years after treatment. Factors positively correlated with loss of visual acuity included: age at start of treatment (p=0.004) and longitudinal basal diameter (p=0.057), while distance of the posterior margin of the tumor from the foveola was inversely correlated (p=0.0007). Conclusion: We identified risk factors affecting visual function and developed a predictive model and decision support tool (AVATAR nomogram).

Pagliara, M. M., Tagliaferri, L., Lenkowicz, J., Azario, L., Giattini, D., Fionda, B., Sammarco, M. G., Lancellotta, V., Gambacorta, M. A., Blasi, M. A., Avatar: Analysis for visual acuity prediction after eye interventional radiotherapy, <<IN VIVO>>, 2020; 34 (1): 381-387. [doi:10.21873/invivo.11784] [http://hdl.handle.net/10807/147534]

Avatar: Analysis for visual acuity prediction after eye interventional radiotherapy

Pagliara, M. M.;Tagliaferri, L.;Lenkowicz, J.;Azario, L.;Gambacorta, M. A.;Blasi, M. A.
2020

Abstract

Aim: The aim of this study was to detect clinical factors predictive of loss of visual acuity after treatment in order to develop a predictive model to help identify patients at risk of visual loss. Patients and Methods: This was a retrospective review of patients who underwent interventional radiotherapy (brachytherapy) with 106Ru plaque for primary uveal melanoma. A predictive nomogram for visual acuity loss at 3 years from treatment was developed. Results: A total of 152 patients were selected for the study. The actuarial probability of conservation of 20/40 vision or better was 0.74 at 1 year, 0.59 at 3 years, and 0.54 at 5 years after treatment. Factors positively correlated with loss of visual acuity included: age at start of treatment (p=0.004) and longitudinal basal diameter (p=0.057), while distance of the posterior margin of the tumor from the foveola was inversely correlated (p=0.0007). Conclusion: We identified risk factors affecting visual function and developed a predictive model and decision support tool (AVATAR nomogram).
Inglese
Pagliara, M. M., Tagliaferri, L., Lenkowicz, J., Azario, L., Giattini, D., Fionda, B., Sammarco, M. G., Lancellotta, V., Gambacorta, M. A., Blasi, M. A., Avatar: Analysis for visual acuity prediction after eye interventional radiotherapy, <<IN VIVO>>, 2020; 34 (1): 381-387. [doi:10.21873/invivo.11784] [http://hdl.handle.net/10807/147534]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/147534
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