In the present manuscript, we review the recent research investigating the pathogenic association between most studied autoantibodies and recurrent pregnancy loss. Pregnancy loss represents a common obstetric complication occurring in about 15%‐25% of all clinically recognized pregnancies. The recurrence of pregnancy loss identifies a distinct clinical entity, that is recurrent pregnancy loss (RPL), affecting about 2%‐4% of couples. Several factors, including age, chromosomal abnormalities, uterine anomalies, thrombophilic disorders, endocrinopathies, hormonal and metabolic disorders, infections, sperm quality, and lifestyle issues, are involved in RPL. The role of autoantibodies in RPL is only partially determined. In some cases (antiphospholipid antibodies [aPL]), their involvement is well established. In other cases (anti‐thyroid autoantibodies, antinuclear, anti‐transglutaminase, and anti‐endomysial antibodies), it is still debated, despite multiple, although not fully conclusive, evidences strongly suggest a possible involvement in RPL. Further extensive research is needed to definitively confirm or exclude their actual role.

D'ippolito, S., Ticconi, C., Tersigni, C., Garofalo, S., Martino, C., Lanzone, A., Scambia, G., Di Simone, N., The pathogenic role of autoantibodies in recurrent pregnancy loss, <<AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY>>, 2020; (Jan;83(1):e13200): 1-9. [doi:10.1111/aji.13200] [http://hdl.handle.net/10807/147389]

The pathogenic role of autoantibodies in recurrent pregnancy loss

Silvia D'Ippolito
Primo
;
Chiara Tersigni
Resources
;
Serafina Garofalo
Resources
;
Carmelinda Martino
Resources
;
Antonio Lanzone
Validation
;
Giovanni Scambia
Validation
;
Nicoletta Di Simone
Conceptualization
2020

Abstract

In the present manuscript, we review the recent research investigating the pathogenic association between most studied autoantibodies and recurrent pregnancy loss. Pregnancy loss represents a common obstetric complication occurring in about 15%‐25% of all clinically recognized pregnancies. The recurrence of pregnancy loss identifies a distinct clinical entity, that is recurrent pregnancy loss (RPL), affecting about 2%‐4% of couples. Several factors, including age, chromosomal abnormalities, uterine anomalies, thrombophilic disorders, endocrinopathies, hormonal and metabolic disorders, infections, sperm quality, and lifestyle issues, are involved in RPL. The role of autoantibodies in RPL is only partially determined. In some cases (antiphospholipid antibodies [aPL]), their involvement is well established. In other cases (anti‐thyroid autoantibodies, antinuclear, anti‐transglutaminase, and anti‐endomysial antibodies), it is still debated, despite multiple, although not fully conclusive, evidences strongly suggest a possible involvement in RPL. Further extensive research is needed to definitively confirm or exclude their actual role.
Inglese
D'ippolito, S., Ticconi, C., Tersigni, C., Garofalo, S., Martino, C., Lanzone, A., Scambia, G., Di Simone, N., The pathogenic role of autoantibodies in recurrent pregnancy loss, <>, 2020; (Jan;83(1):e13200): 1-9. [doi:10.1111/aji.13200] [http://hdl.handle.net/10807/147389]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/147389
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 17
  • ???jsp.display-item.citation.isi??? 15
social impact