The test of short latency afferent inhibition (SAI) of the motor cortex is helpful in demonstrating dysfunction of central cholinergic circuits in Alzheimer disease (AD). The authors evaluated SAI in 20 patients with frontotemporal dementia (FTD) and compared data with those from 20 patients with AD and 20 controls. SAI was normal in FTD, whereas it was reduced in AD. SAI may represent an additional tool to discriminate FTD from AD. Copyright © 2006 by AAN Enterprises, Inc.
Di Lazzaro, V., Pilato, F., Dileone, M., Saturno, E., Oliviero, A., Marra, C., Daniele, A., Ranieri, F., Gainotti, G., Tonali, P. A., In vivo cholinergic circuit evaluation in frontotemporal and Alzheimer dementias, <<NEUROLOGY>>, 2006; 66 (7): 1111-1113. [doi:10.1212/01.wnl.0000204183.26231.23] [http://hdl.handle.net/10807/141738]
In vivo cholinergic circuit evaluation in frontotemporal and Alzheimer dementias
Di Lazzaro, Vincenzo;Pilato, Fabio;Marra, Camillo;Daniele, Antonio;Ranieri, Federico;Gainotti, Guido;
2006
Abstract
The test of short latency afferent inhibition (SAI) of the motor cortex is helpful in demonstrating dysfunction of central cholinergic circuits in Alzheimer disease (AD). The authors evaluated SAI in 20 patients with frontotemporal dementia (FTD) and compared data with those from 20 patients with AD and 20 controls. SAI was normal in FTD, whereas it was reduced in AD. SAI may represent an additional tool to discriminate FTD from AD. Copyright © 2006 by AAN Enterprises, Inc.
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