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EnglishObjective: we assessed the association between baseline eosinophil cationic protein (ECP) levels, a sensitive marker of eosinophil activation, and clinical outcome in patients undergoing bare metal stent (BMS) implantation. Methods: basal ECP levels were measured in 110 patients (69±11 years, 88 men) undergoingBMSimplantation. Major adverse cardiac events (MACEs), defined as cardiac death, non-fatal myocardial infarction, or clinically-driven target lesion revascularization, were registered at 24-month follow-up. Results: eighteen (16.4%) patients had MACEs and showed higher ECP levels compared with those without MACEs [20.1 (9.8 47.3) vs. 9.5 (5.0 27.2) g/L, p = 0.02]. At follow-up, ECP level >11 g/L was the only significant predictor of MACEs (HR 3.5, 95% CI 1.1 10.4, p = 0.03). Conclusion: basal ECP levels are associated with MACEs after BMS implantation, suggesting that an allergic-mediated inflammation against the metal could explain some adverse reactions occurring after coronary stenting.
| Autori: | |
| Titolo: | Eosinophil cationic protein and clinical outcome after bare metal stent implantation |
| Digital Object Identifier (DOI): | http://dx.doi.org/21183182 |
| Data di pubblicazione: | 2011 |
| Abstract: | Objective: we assessed the association between baseline eosinophil cationic protein (ECP) levels, a sensitive marker of eosinophil activation, and clinical outcome in patients undergoing bare metal stent (BMS) implantation. Methods: basal ECP levels were measured in 110 patients (69±11 years, 88 men) undergoingBMSimplantation. Major adverse cardiac events (MACEs), defined as cardiac death, non-fatal myocardial infarction, or clinically-driven target lesion revascularization, were registered at 24-month follow-up. Results: eighteen (16.4%) patients had MACEs and showed higher ECP levels compared with those without MACEs [20.1 (9.8 47.3) vs. 9.5 (5.0 27.2) g/L, p = 0.02]. At follow-up, ECP level >11 g/L was the only significant predictor of MACEs (HR 3.5, 95% CI 1.1 10.4, p = 0.03). Conclusion: basal ECP levels are associated with MACEs after BMS implantation, suggesting that an allergic-mediated inflammation against the metal could explain some adverse reactions occurring after coronary stenting. |
| Lingua: | Inglese |
| Rivista: | |
| Citazione: | Niccoli, G., Sgueglia, G. A., Conte, M., Cosentino, N., Minelli, S., Belloni, F., Trani, C., Sabato, V., Burzotta, F., Porto, I., Leone, A. M., Schiavino, D., Crea, F., Eosinophil cationic protein and clinical outcome after bare metal stent implantation, <<ATHEROSCLEROSIS>>, 2011; 215 (Marzo): 166-169. [doi:21183182] [http://hdl.handle.net/10807/13701] |
| Appare nelle tipologie: | Articolo in rivista, Nota a sentenza |
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